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Self-transcendence trait and its relationship with in vivo serotonin transporter availability in brainstem raphe nuclei: An ultra-high resolution PET-MRI study

Authors
Kim, Jong-HoonSon, Young-DonKim, Jeong-HeeChoi, Eun-JungLee, Sang-YoonJoo, Yo-HanKim, Young-BoCho, Zang-Hee
Issue Date
10-12월-2015
Publisher
ELSEVIER SCIENCE BV
Keywords
Self-transcendence; Serotonin transporter; Raphe nucleus; Magnetic resonance imaging; Positron emission tomography; [C-11]DASB
Citation
BRAIN RESEARCH, v.1629, pp.63 - 71
Indexed
SCIE
SCOPUS
Journal Title
BRAIN RESEARCH
Volume
1629
Start Page
63
End Page
71
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/91582
DOI
10.1016/j.brainres.2015.10.006
ISSN
0006-8993
Abstract
Self-transcendence is an inherent human personality trait relating to the experience of spiritual aspects of the self. We examined the relationship between self-transcendence and serotonin transporter (SERT) availability in brainstem raphe nuclei, which are collections of five different serotonergic nuclei with rostro-caudal extension, using ultra-high resolution magnetic resonance imaging (Mm) and positron emission tomography (PET) with C-11-3-amino-4-(2-dimethylaminomethylphenylthio)benzonitrile ([C-11]DASB) to elucidate potential roles of serotonergic neuronal activities in this personality trait. Sixteen healthy subjects completed 7.0 T MRI and High Resolution Research Tomograph (HRRT) PET. The regions of interest (ROIs) included the dorsal raphe nucleus (R1), median raphe nucleus (R2), raphe ponds (R3), and the caudal raphe nuclei (R4 and R5). For the estimation of SERT availability, the binding potential (BPND) was derived using the simplified reference tissue model (SRTM2). The Temperament and Character Inventory was used to measure self-transcendence. The analysis revealed that the self-transcendence total score had a significant negative correlation with the [C-11]DASB BPND in the caudal raphe (R5). The subscale score for spiritual acceptance was significantly negatively correlated with the [C-11] DASB BPND in the median raphe nucleus (R2). The results indicate that the self-transcendence trait is associated with SERT availability in specific raphe subnuclei, suggesting that the serotonin system may serve as an important biological basis for human self-transcendence. Based on the connections of these nuclei with cortico-limbic and visceral autonomic structures, the functional activity of these nuclei and their related neural circuitry may play a crucial role in the manifestation of self-transcendence. (C) 2015 Published by Elsevier B.V.
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