Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun Jung | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Ko, Eun Jung | - |
dc.contributor.author | Yoon, Eileen L. | - |
dc.contributor.author | Suh, Sang Jun | - |
dc.contributor.author | Kang, Keunhee | - |
dc.contributor.author | Kim, Hae Rim | - |
dc.contributor.author | Kang, Seoung Hee | - |
dc.contributor.author | Yoo, Yang Jae | - |
dc.contributor.author | Je, Jihye | - |
dc.contributor.author | Lee, Beom Jae | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Byun, Kwan Soo | - |
dc.date.accessioned | 2021-09-04T09:20:27Z | - |
dc.date.available | 2021-09-04T09:20:27Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-12-07 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/91597 | - |
dc.description.abstract | AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors (PPAR)-delta agonist treatment in nonalcoholic fatty liver disease (NAFLD) models. METHODS: Male C57BL/6J mice were classified according to control or high fat diet (HFD) with or without PPAR-delta agonist (GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide (LPS), HFD + LPS + GW group]. HepG2 cells were exposed to palmitic acid (PA) and/or LPS in the absence or presence of GW. RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin (IL)-1 beta in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In HepG2 cells, PA and LPS treatment markedly increased mRNA of several nucleotide-binding and oligomerization domain-like receptor family members (NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1 beta. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-alpha. CONCLUSION: PPAR-delta agonist reduces fatty acid-induced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-delta agonist may have therapeutic implication for NAFLD. Key words: Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Inflammasome; Nucleotide-binding and oligomerization domain-like receptor; Peroxisome proliferator-activated receptors delta | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BAISHIDENG PUBLISHING GROUP INC | - |
dc.subject | NLRP3 INFLAMMASOME | - |
dc.subject | INSULIN SENSITIVITY | - |
dc.subject | OVERWEIGHT PATIENTS | - |
dc.subject | GLUCOSE-METABOLISM | - |
dc.subject | MEDITERRANEAN DIET | - |
dc.subject | STEATOHEPATITIS | - |
dc.subject | ACID | - |
dc.subject | OBESITY | - |
dc.subject | EXPRESSION | - |
dc.subject | MICE | - |
dc.title | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yeon, Jong Eun | - |
dc.contributor.affiliatedAuthor | Kim, Ji Hoon | - |
dc.contributor.affiliatedAuthor | Yim, Hyung Joon | - |
dc.contributor.affiliatedAuthor | Byun, Kwan Soo | - |
dc.identifier.doi | 10.3748/wjg.v21.i45.12787 | - |
dc.identifier.scopusid | 2-s2.0-84948972849 | - |
dc.identifier.wosid | 000365966600006 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, v.21, no.45, pp.12787 - 12799 | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.title | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.volume | 21 | - |
dc.citation.number | 45 | - |
dc.citation.startPage | 12787 | - |
dc.citation.endPage | 12799 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | NLRP3 INFLAMMASOME | - |
dc.subject.keywordPlus | INSULIN SENSITIVITY | - |
dc.subject.keywordPlus | OVERWEIGHT PATIENTS | - |
dc.subject.keywordPlus | GLUCOSE-METABOLISM | - |
dc.subject.keywordPlus | MEDITERRANEAN DIET | - |
dc.subject.keywordPlus | STEATOHEPATITIS | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | Nonalcoholic fatty liver disease | - |
dc.subject.keywordAuthor | Nonalcoholic steatohepatitis | - |
dc.subject.keywordAuthor | Inflammasome | - |
dc.subject.keywordAuthor | Nucleotide-binding and oligomerization domain-like receptor | - |
dc.subject.keywordAuthor | Peroxisome proliferator-activated receptors delta | - |
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