Immediate Effects of 3% Diquafosol and 0.1% Hyaluronic Acid Ophthalmic Solution on Tear Break-Up Time in Normal Human Eyes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, Ki Tae | - |
dc.contributor.author | Ahn, So Min | - |
dc.contributor.author | Eom, Youngsub | - |
dc.contributor.author | Kim, Hyo Myung | - |
dc.contributor.author | Song, Jong Suk | - |
dc.date.accessioned | 2021-09-04T09:46:22Z | - |
dc.date.available | 2021-09-04T09:46:22Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-12-01 | - |
dc.identifier.issn | 1080-7683 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/91631 | - |
dc.description.abstract | Purpose: The purpose of this study was to evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear break-up time (TBUT) in normal human eyes, and to compare it with that of saline and 0.1% hyaluronate ophthalmic solution. Methods: Cross sectional comparative study in the first study, 10 healthy volunteers underwent topical application of 2 different ophthalmic solutions in each eye. Saline was randomly applied to one eye and 3% diquafosol ophthalmic solution was added to the fellow eye. TBUT was measured and video recorded before application and at 5, 10, 15, and 20min after. The TBUT in each eye was compared at each time point with regard to the 2 different ophthalmic solutions. In the second study, another 10 healthy volunteers were included. The same methods were used to compare the immediate effects of 0.1% hyaluronate and 3% diquafosol ophthalmic solution application on TBUT. Results: In the first study, topical instillation of saline did not increase TBUT. However, 3% diquafosol significantly increased TBUT for up to 15min after application. At every time point, the TBUT increased more significantly from baseline in the diquafosol group than it did in the saline group. In the second study, 0.1% hyaluronate increased TBUT for up to 5min after application, while 3% diquafosol increased TBUT for up to 15min. Although the TBUT changes after 5min were not significantly different between the 2 groups, the TBUT changes at 10, 15, and 20min were significantly greater in the 3% diquafosol group than they were in the 0.1% hyaluronic acid group (+1.580.82 vs. +0.53 +/- 1.36 at 10min, +0.67 +/- 0.91 vs. -0.04 +/- 1.29 at 15min, and -0.06 +/- 0.96 vs. -0.59 +/- 0.90, diquafosol group vs. hyaluronic acid group). Conclusions: One drop of 3% diquafosol increased TBUT for up to 15min after application. The immediate effect of 3% diquafosol on TBUT was greater than that of saline and even that of 1% hyaluronate ophthalmic solution. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | DRY EYE | - |
dc.subject | GOBLET CELLS | - |
dc.subject | SECRETION | - |
dc.subject | RABBIT | - |
dc.subject | FILM | - |
dc.subject | GLYCOPROTEIN | - |
dc.subject | TETRASODIUM | - |
dc.subject | CONJUNCTIVA | - |
dc.subject | EFFICACY | - |
dc.subject | SAFETY | - |
dc.title | Immediate Effects of 3% Diquafosol and 0.1% Hyaluronic Acid Ophthalmic Solution on Tear Break-Up Time in Normal Human Eyes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Eom, Youngsub | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Myung | - |
dc.contributor.affiliatedAuthor | Song, Jong Suk | - |
dc.identifier.doi | 10.1089/jop.2015.0062 | - |
dc.identifier.scopusid | 2-s2.0-84973309351 | - |
dc.identifier.wosid | 000365694500008 | - |
dc.identifier.bibliographicCitation | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, v.31, no.10, pp.631 - 635 | - |
dc.relation.isPartOf | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS | - |
dc.citation.title | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS | - |
dc.citation.volume | 31 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 631 | - |
dc.citation.endPage | 635 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | DRY EYE | - |
dc.subject.keywordPlus | GOBLET CELLS | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | RABBIT | - |
dc.subject.keywordPlus | FILM | - |
dc.subject.keywordPlus | GLYCOPROTEIN | - |
dc.subject.keywordPlus | TETRASODIUM | - |
dc.subject.keywordPlus | CONJUNCTIVA | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | SAFETY | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.