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Spatiotemporal Patterns of Cortical Fiber Density in Developing Infants, and Their Relationship With Cortical Thickness

Authors
Li, GangLiu, TianmingNi, DongLin, WeiliGilmore, John H.Shen, Dinggang
Issue Date
12월-2015
Publisher
WILEY
Keywords
infant; cortical surface; fiber density; cortical folding; cortical thickness; longitudinal development
Citation
HUMAN BRAIN MAPPING, v.36, no.12, pp.5183 - 5195
Indexed
SCIE
SCOPUS
Journal Title
HUMAN BRAIN MAPPING
Volume
36
Number
12
Start Page
5183
End Page
5195
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/91669
DOI
10.1002/hbm.23003
ISSN
1065-9471
Abstract
The intrinsic relationship between the convoluted cortical folding and the underlying complex whiter matter fiber connections has received increasing attention in current neuroscience studies. Recently, the axonal pushing hypothesis of cortical folding has been proposed to explain the finding that the axonal fibers (derived from diffusion tensor images) connecting to gyri are significantly denser than those connecting to sulci in both adult human and non-human primate brains. However, it is still unclear about the spatiotemporal patterns of the fiber density on the cortical surface of the developing infant brains from birth to 2 years of age, which is the most dynamic phase of postnatal brain development. In this paper, for the first time, we systemically characterized the spatial distributions and longitudinal developmental trajectories of the cortical fiber density in the first 2 postnatal years, via joint analysis of longitudinal structural and diffusion tensor imaging from 33 healthy infants. We found that the cortical fiber density increases dramatically in the first year and then keeps relatively stable in the second year. Moreover, we revealed that the cortical fiber density on gyral regions was significantly higher at 0, 1, and 2 years of age than that on sulcal regions in the frontal, temporal, and parietal lobes. Meanwhile, the cortical fiber density was strongly positively correlated with cortical thickness at several three-hinge junction regions of gyri. These results significantly advanced our understanding of the intrinsic relationship between the cortical folding, cortical thickness and axonal wiring during early postnatal stages. (C) 2015 Wiley Periodicals, Inc.
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