Association between FCGR3B copy number variations and susceptibility to autoimmune diseases: a meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Seo, Young Ho | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-04T09:59:22Z | - |
dc.date.available | 2021-09-04T09:59:22Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1023-3830 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/91699 | - |
dc.description.abstract | This study determined whether FCGR3B copy number variations (CNVs) were associated with susceptibility to autoimmune diseases. A meta-analysis was conducted to determine the association between FCGR3B CNVs and susceptibility to autoimmune diseases by comparing low FCGR3B CN (< 2 to a parts per thousand yen2) and high FCGR3B CN (> 2 to a parts per thousand currency sign2). In all, 28 comparative studies from 15 reports involving 12,160 patients and 11,103 controls were included in this meta-analysis. The meta-analysis showed a significant association between low FCGR3B CN and autoimmune diseases (OR = 1.496, 95 % CI = 1.301-1.716, p = 1.0 x 10(-9)). Subgroup analysis according to ethnicity indicated an association between low FCGR3B CN and autoimmune diseases in Caucasians (OR = 1.482, 95 % CI = 1.219-1.801, p = 7.7 x 10(-6)) and Asians (OR = 1.498, 95 % CI = 1.306-1.717, p = 1.0 x 10(-9)). Meta-analysis according to the type of autoimmune disease indicated a significant association of low FCGR3B CN with systemic lupus erythematosus (SLE; OR = 1.797, 95 % CI = 1.562-2.068, p < 1.0 x 10(-9)), primary Sjogren's syndrome (pSS; OR = 2.263, 95 % CI = 1.316-3.892, p = 0.003), and Wegener's granulomatosis (WG; OR = 1.973, 95 % CI = 1.178-3.302, p = 0.010), but not with rheumatoid arthritis (RA; OR = 1.333, 95 % CI = 0.947-1.877, p = 0.099). However, the meta-analysis showed no association between high FCGR3B CN and SLE, RA, pSS, and WG. Thus, the results of this meta-analysis indicated that low FCGR3B CN increased susceptibility to autoimmune diseases, especially SLE, pSS, and WG. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER BASEL AG | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | RISK-FACTOR | - |
dc.subject | GENE | - |
dc.subject | POLYMORPHISMS | - |
dc.subject | PATHOGENESIS | - |
dc.subject | RECEPTORS | - |
dc.subject | DELETION | - |
dc.subject | RATHER | - |
dc.subject | LOCUS | - |
dc.title | Association between FCGR3B copy number variations and susceptibility to autoimmune diseases: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hoon | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s00011-015-0882-1 | - |
dc.identifier.scopusid | 2-s2.0-84945461721 | - |
dc.identifier.wosid | 000363974100006 | - |
dc.identifier.bibliographicCitation | INFLAMMATION RESEARCH, v.64, no.12, pp.983 - 991 | - |
dc.relation.isPartOf | INFLAMMATION RESEARCH | - |
dc.citation.title | INFLAMMATION RESEARCH | - |
dc.citation.volume | 64 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 983 | - |
dc.citation.endPage | 991 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | DELETION | - |
dc.subject.keywordPlus | RATHER | - |
dc.subject.keywordPlus | LOCUS | - |
dc.subject.keywordAuthor | Autoimmune diseases | - |
dc.subject.keywordAuthor | FCGR3B | - |
dc.subject.keywordAuthor | Copy number variation | - |
dc.subject.keywordAuthor | Meta-analysis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.