Safety and Efficacy of Rice Bran Supercritical CO2 Extract for Hair Growth in Androgenic Alopecia: A 16-Week Double-Blind Randomized Controlled Trial
DC Field | Value | Language |
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dc.contributor.author | Choi, Jae-Suk | - |
dc.contributor.author | Park, Jae Beom | - |
dc.contributor.author | Moon, Woi-Sook | - |
dc.contributor.author | Moon, Jin-Nam | - |
dc.contributor.author | Son, Sang Wook | - |
dc.contributor.author | Kim, Mi-Ryung | - |
dc.date.accessioned | 2021-09-04T10:05:37Z | - |
dc.date.available | 2021-09-04T10:05:37Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/91744 | - |
dc.description.abstract | We conducted a 16-week double-blind randomized controlled single-center trial to evaluate the safety and efficacy of dermal rice bran supercritical CO, extract (RB-SCE) in the treatment of androgenic alopecia. Fifty alopecia patients were randomly assigned to the experimental and placebo groups. The experimental group received a dermal application of 0.5% RB-SCE (8 mL/d) to the head skin for 16 weeks while the control group received a dermal application of placebo. Changes in hair count, diameter, and density were evaluated with a Folliscope. Patient satisfaction was evaluated via questionnaire and clinical photographs were rated by dermatologists. The results showed that RB-SCE significantly increased hair density and hair diameter in male subjects. Patient satisfaction and the evaluation of photographs by dermatologists also confirmed the effectiveness of RB-SCE in the treatment of alopecia. No adverse reactions related to RB-SCE were reported. Therefore, RB-SCE shows promise for use in functional cosmetics and pharmaceuticals. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.subject | 2-PERCENT TOPICAL MINOXIDIL | - |
dc.subject | CONTACT-DERMATITIS | - |
dc.subject | CLINICAL-TRIAL | - |
dc.subject | 5-ALPHA-REDUCTASE | - |
dc.subject | INHIBITION | - |
dc.subject | PLACEBO | - |
dc.subject | FINASTERIDE | - |
dc.subject | 5-PERCENT | - |
dc.subject | TOXICITY | - |
dc.subject | AREATA | - |
dc.title | Safety and Efficacy of Rice Bran Supercritical CO2 Extract for Hair Growth in Androgenic Alopecia: A 16-Week Double-Blind Randomized Controlled Trial | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Son, Sang Wook | - |
dc.identifier.doi | 10.1248/bpb.b15-00387 | - |
dc.identifier.scopusid | 2-s2.0-84948658243 | - |
dc.identifier.wosid | 000365694800005 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.38, no.12, pp.1856 - 1863 | - |
dc.relation.isPartOf | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.title | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 38 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1856 | - |
dc.citation.endPage | 1863 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | 2-PERCENT TOPICAL MINOXIDIL | - |
dc.subject.keywordPlus | CONTACT-DERMATITIS | - |
dc.subject.keywordPlus | CLINICAL-TRIAL | - |
dc.subject.keywordPlus | 5-ALPHA-REDUCTASE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | PLACEBO | - |
dc.subject.keywordPlus | FINASTERIDE | - |
dc.subject.keywordPlus | 5-PERCENT | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | AREATA | - |
dc.subject.keywordAuthor | rice bran supercritical CO2 extract | - |
dc.subject.keywordAuthor | hair growth-promoting activity | - |
dc.subject.keywordAuthor | alopecia | - |
dc.subject.keywordAuthor | clinical study | - |
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