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Pathophysiological Changes Induced by Pseudomonas aeruginosa Infection Are Involved in MMP-12 and MMP-13 Upregulation in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model

Authors
Park, Ji-WonShin, In-SikHa, Un-HwanOh, Sei-RyangKim, Jae-HongAhn, Kyong-Seop
Issue Date
12월-2015
Publisher
AMER SOC MICROBIOLOGY
Citation
INFECTION AND IMMUNITY, v.83, no.12, pp.4791 - 4799
Indexed
SCIE
SCOPUS
Journal Title
INFECTION AND IMMUNITY
Volume
83
Number
12
Start Page
4791
End Page
4799
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/91759
DOI
10.1128/IAI.00619-15
ISSN
0019-9567
Abstract
Pseudomonas aeruginosa infections persist in patients with cystic fibrosis (CF) and drive lung disease progression. P. aeruginosa potently activates the innate immune system mostly through the recognition of pathogen-associated molecular patterns, such as flagellin. Matrix metalloproteinases 12 and 13 (MMP-12 and MMP-13, respectively) exacerbate chronic lung infection and inflammation by promoting uncontrolled tissue rearrangements and fibrosis, yet the underlying molecular mechanisms by which this occurs remain largely unknown. In this study, we used quantitative bacteriology, histological examination, and proinflammatory cytokine levels to evaluate the effects of MMP-12 and MMP-13 on P. aeruginosa strain K-induced infection and pneumonia in H292 epithelial cells and mice, respectively. Under inflammatory stimulation, mRNA and protein expression levels of proinflammatory mediators were higher in strain K-infected mice and cells than in uninfected counterparts, in which MMP-12 and MMP-13 expression reached levels similar to those observed in epithelial cells. Moreover, we also found that the NF-kappa B pathway might be involved in the induction of cytokines in response to strain K infection. Taken together, these data suggest that MMP-12 and MMP-13 alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.
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