Co-delivery of platelet-derived growth factor (PDGF-BB) and bone morphogenic protein (BMP-2) coated onto heparinized titanium for improving osteoblast function and osteointegration
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Yun, Young-Pil | - |
dc.contributor.author | Lee, Jae Yong | - |
dc.contributor.author | Shim, June-Sung | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Huh, Jung-Bo | - |
dc.date.accessioned | 2021-09-04T10:10:08Z | - |
dc.date.available | 2021-09-04T10:10:08Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1932-6254 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/91774 | - |
dc.description.abstract | The aim of this study was to improve osteoblast function by delivering two growth factors, PDGF-BB and BMP-2, incorporated onto heparinized titanium (Hep-Ti) substrate. To achieve co-delivery of PDGF-BB and BMP-2, the surface of anodized Ti was immobilized with heparin, and then the two growth factors were coated onto the Hep-Ti surface. Incorporation of the two growth factors onto Hep-Ti was evaluated by SEM and XPS. Incorporated PDGF-BB and BMP-2 were released from the Hep-Ti substrate in a sustained manner. In vitro studies revealed that osteoblasts grown on PDGF-BB-and BMP-2-immobilized Hep-Ti increased ALP activity, calcium deposition, osteocalcin and osteopontin levels as compared to those grown on PDGF-BB alone-or BMP-2 alone-immobilized Hep-Ti. These results suggested that co-delivery of PDGF-BB and BMP-2 using Hep-Ti substrate will be a promising material for the enhancement of osteoblast function and osteointegration. Copyright (C) 2013 John Wiley & Sons, Ltd. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | MESENCHYMAL STEM-CELLS | - |
dc.subject | BACTERIAL ADHESION | - |
dc.subject | REGENERATION | - |
dc.subject | IMMOBILIZATION | - |
dc.subject | NANOPARTICLES | - |
dc.subject | INFLAMMATION | - |
dc.subject | ENHANCEMENT | - |
dc.subject | DEFECTS | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | COMBINATION | - |
dc.title | Co-delivery of platelet-derived growth factor (PDGF-BB) and bone morphogenic protein (BMP-2) coated onto heparinized titanium for improving osteoblast function and osteointegration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sung Eun | - |
dc.identifier.doi | 10.1002/term.1668 | - |
dc.identifier.scopusid | 2-s2.0-84955188328 | - |
dc.identifier.wosid | 000368521100007 | - |
dc.identifier.bibliographicCitation | JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.9, no.12, pp.E219 - E228 | - |
dc.relation.isPartOf | JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.citation.title | JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | E219 | - |
dc.citation.endPage | E228 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | BACTERIAL ADHESION | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | IMMOBILIZATION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | DEFECTS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordAuthor | titanium implant | - |
dc.subject.keywordAuthor | PDGF-BB | - |
dc.subject.keywordAuthor | BMP-2 | - |
dc.subject.keywordAuthor | osteoblast | - |
dc.subject.keywordAuthor | osteointegration | - |
dc.subject.keywordAuthor | bone regeneration | - |
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