Anti-adipogenic effect of oat hull extract containing tricin on 3T3-L1 adipocytes
DC Field | Value | Language |
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dc.contributor.author | Lee, Dabeen | - |
dc.contributor.author | Park, Hyeong Yeol | - |
dc.contributor.author | Kim, Sohyun | - |
dc.contributor.author | Park, Yooheon | - |
dc.contributor.author | Bang, Myun-Ho | - |
dc.contributor.author | Imm, Jee-Young | - |
dc.date.accessioned | 2021-09-04T10:12:02Z | - |
dc.date.available | 2021-09-04T10:12:02Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1359-5113 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/91788 | - |
dc.description.abstract | Oat hull ethyl acetate extract (50 mu g/mu L) significantly inhibited triglyceride accumulation in 3T3-L1 adipocytes without causing cytotoxicity. The major active compound in the extract was isolated and identified as 5,7,4'-trihydroxy-3',5'-dimethoxyflavone, tricin by mass spectrometry and 1H and C-13 NMR analyses. The tricin content in oat hull was approximately 18 mg/kg dry weight, and tricib constituted 9.6% of the total phenolic compounds in oat hull extract. The treatment of 3T3-L1 cells either with extract or purified tricin resulted in decreased lipid accumulation. The extract significantly decreased the activity of glycerol-3-phosphate dyhydrogenase, a marker of adipocyte differentiation in a dose dependent manner. The expression of major transcription factors, such as peroxisome proliferator-activated receptor (PPAR)-gamma, CCATT/enhancer binding protein-alpha (CEBP/alpha), sterol regulatory binding protein 1 (SREBP1) and fatty acid synthase (FAS) was also significantly suppressed by the extract. When commercial purified tricin was added to 3T3-L1 cells the expression of all transcription factors were significantly decreased as low as 1.5 mu g/mu L treatment. These results suggest that oat hull extract containing tricin possesses anti-adipogeneic effect. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | ANTIOXIDANTS | - |
dc.subject | OBESITY | - |
dc.subject | FLAVONES | - |
dc.subject | CELLS | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | METHYLATION | - |
dc.subject | METABOLISM | - |
dc.subject | INCREASES | - |
dc.subject | OXIDATION | - |
dc.subject | NJAVARA | - |
dc.title | Anti-adipogenic effect of oat hull extract containing tricin on 3T3-L1 adipocytes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yooheon | - |
dc.identifier.doi | 10.1016/j.procbio.2015.09.019 | - |
dc.identifier.scopusid | 2-s2.0-84948981298 | - |
dc.identifier.wosid | 000367125900039 | - |
dc.identifier.bibliographicCitation | PROCESS BIOCHEMISTRY, v.50, no.12, pp.2314 - 2321 | - |
dc.relation.isPartOf | PROCESS BIOCHEMISTRY | - |
dc.citation.title | PROCESS BIOCHEMISTRY | - |
dc.citation.volume | 50 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2314 | - |
dc.citation.endPage | 2321 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | ANTIOXIDANTS | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | FLAVONES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | METHYLATION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | INCREASES | - |
dc.subject.keywordPlus | OXIDATION | - |
dc.subject.keywordPlus | NJAVARA | - |
dc.subject.keywordAuthor | Oat hull extract | - |
dc.subject.keywordAuthor | 3T3-L1 adipocytes | - |
dc.subject.keywordAuthor | Tricin | - |
dc.subject.keywordAuthor | Adipogenesis | - |
dc.subject.keywordAuthor | Transcription factors | - |
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