Protective role of edaravone against cisplatin-induced ototoxicity in an auditory cell line
DC Field | Value | Language |
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dc.contributor.author | Im, Gi Jung | - |
dc.contributor.author | Chang, Jiwon | - |
dc.contributor.author | Lee, Sehee | - |
dc.contributor.author | Choi, June | - |
dc.contributor.author | Jung, Hak Hyun | - |
dc.contributor.author | Lee, Hyung Min | - |
dc.contributor.author | Ryu, Sung Hoon | - |
dc.contributor.author | Park, Su Kyoung | - |
dc.contributor.author | Kim, Jin Hwan | - |
dc.contributor.author | Kim, Hyung-Jong | - |
dc.date.accessioned | 2021-09-04T10:15:59Z | - |
dc.date.available | 2021-09-04T10:15:59Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 0378-5955 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/91818 | - |
dc.description.abstract | Edaravone is a neuroprotective agent with a potent free radical scavenging and antioxidant actions. In the present study we investigated the influence of edaravone on cisplatin ototoxicity in auditory cells. Cell viability was determined using a 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide cell proliferation assay. Oxidative stress and apoptosis were assessed by reactive oxygen species (ROS) measurement, Hoechst 33258 staining, caspase-3 activity assay, and immunoblotting of PARP. Pretreatment with 100 mu M of edaravone prior to application of 15 mu M of cisplatin increased cell viability after 48 h of incubation in HEI-OC1 cells (from 51.9% to 64. 6% viability) and also, attenuated the cisplatin-induced increase in reactive oxygen species (ROS) (from 2.3 fold to 1.9 fold). Edaravone also decreased the activation of caspase-3 and reduced levels of cleaved poly-ADP-ribose polymerase (PARP). We propose that edaravone protects against cisplatin-induced ototoxicity by preventing apoptosis, and limiting ROS production in HEI-OC1 cells. This article is part of a Special Issue entitled <IEB Kyoto>. (C) 2015 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | FREE-RADICAL SCAVENGER | - |
dc.subject | HAIR CELL | - |
dc.subject | INJURY | - |
dc.title | Protective role of edaravone against cisplatin-induced ototoxicity in an auditory cell line | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Im, Gi Jung | - |
dc.contributor.affiliatedAuthor | Choi, June | - |
dc.contributor.affiliatedAuthor | Jung, Hak Hyun | - |
dc.identifier.doi | 10.1016/j.heares.2015.08.004 | - |
dc.identifier.scopusid | 2-s2.0-84948766014 | - |
dc.identifier.wosid | 000367492100014 | - |
dc.identifier.bibliographicCitation | HEARING RESEARCH, v.330, pp.113 - 118 | - |
dc.relation.isPartOf | HEARING RESEARCH | - |
dc.citation.title | HEARING RESEARCH | - |
dc.citation.volume | 330 | - |
dc.citation.startPage | 113 | - |
dc.citation.endPage | 118 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Audiology & Speech-Language Pathology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Audiology & Speech-Language Pathology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.subject.keywordPlus | FREE-RADICAL SCAVENGER | - |
dc.subject.keywordPlus | HAIR CELL | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordAuthor | Edaravone | - |
dc.subject.keywordAuthor | Cisplatin | - |
dc.subject.keywordAuthor | Ototoxicity | - |
dc.subject.keywordAuthor | Cell culture | - |
dc.subject.keywordAuthor | Apoptosis | - |
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