Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning
DC Field | Value | Language |
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dc.contributor.author | Park, Hanwool | - |
dc.contributor.author | Yang, Jinhee | - |
dc.contributor.author | Kim, Ryunhee | - |
dc.contributor.author | Li, Yan | - |
dc.contributor.author | Lee, Yeunkum | - |
dc.contributor.author | Lee, Chungwoo | - |
dc.contributor.author | Park, Jongil | - |
dc.contributor.author | Lee, Dongmin | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Kim, Eunjoon | - |
dc.date.accessioned | 2021-09-04T10:45:10Z | - |
dc.date.available | 2021-09-04T10:45:10Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2015-11-10 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/91919 | - |
dc.description.abstract | Protein ubiquitination has a significant influence on diverse aspects of neuronal development and function. Dorfin, also known as Rnf19a, is a RING finger E3 ubiquitin ligase implicated in amyotrophic lateral sclerosis and Parkinson's disease, but its in vivo functions have not been explored. We report here that Dorfin is a novel binding partner of the excitatory postsynaptic scaffolding protein PSD95. Dorfin-mutant (Dorfin(-/-)) mice show reduced adult neurogenesis and enhanced long-term potentiation in the hippocampal dentate gyrus, but normal long-term potentiation in the CA1 region. Behaviorally, Dorfin(-/-) mice show impaired contextual fear conditioning, but normal levels of cued fear conditioning, fear extinction, spatial learning and memory, object recognition memory, spatial working memory, and pattern separation. Using a proteomic approach, we also identify a number of proteins whose ubiquitination levels are decreased in the Dorfin(-/-) brain. These results suggest that Dorfin may regulate adult neurogenesis, synaptic plasticity, and contextual fear memory. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | ACTIVITY-DEPENDENT UBIQUITINATION | - |
dc.subject | RING-FINGER PROTEIN | - |
dc.subject | AMPA RECEPTORS | - |
dc.subject | HIPPOCAMPAL NEUROGENESIS | - |
dc.subject | SYNAPTIC PLASTICITY | - |
dc.subject | UBIQUITYLATED INCLUSIONS | - |
dc.subject | RECYCLING ENDOSOMES | - |
dc.subject | PATTERN SEPARATION | - |
dc.subject | DORFIN LOCALIZES | - |
dc.subject | DENTATE GYRUS | - |
dc.title | Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun | - |
dc.identifier.doi | 10.1038/srep16410 | - |
dc.identifier.scopusid | 2-s2.0-84946950124 | - |
dc.identifier.wosid | 000364385500002 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.5 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ACTIVITY-DEPENDENT UBIQUITINATION | - |
dc.subject.keywordPlus | RING-FINGER PROTEIN | - |
dc.subject.keywordPlus | AMPA RECEPTORS | - |
dc.subject.keywordPlus | HIPPOCAMPAL NEUROGENESIS | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | UBIQUITYLATED INCLUSIONS | - |
dc.subject.keywordPlus | RECYCLING ENDOSOMES | - |
dc.subject.keywordPlus | PATTERN SEPARATION | - |
dc.subject.keywordPlus | DORFIN LOCALIZES | - |
dc.subject.keywordPlus | DENTATE GYRUS | - |
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