A probable case of syndrome of inappropriate antidiuretic hormone secretion associated with linezolid
- Authors
- Baik, Seung Hee; Choi, Yoon Kyung; Kim, Hyun Seo; Yoon, Young Kyung; Sohn, Jang Wook; Kim, Min Ja
- Issue Date
- 1-11월-2015
- Publisher
- AMER SOC HEALTH-SYSTEM PHARMACISTS
- Citation
- AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, v.72, no.21, pp.1865 - 1869
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
- Volume
- 72
- Number
- 21
- Start Page
- 1865
- End Page
- 1869
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/91954
- DOI
- 10.2146/ajhp150208
- ISSN
- 1079-2082
- Abstract
- Purpose. A probable case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) due to linezolid use is reported. Summary. An 81-year-old Korean woman hospitalized for progressive malignant otitis externa due to methicillin-resistant Staphylococcus aureus infection was started on linezolid therapy (600 mg iv. twice daily). On day 22 of linezolid use, the patient had severe hyponatremia (serum sodium concentration, 118 meq/L), with stable vital signs and no specific physical findings except for somnolence. The patient's urine sodium concentration was 1183 meq/L, and her serum and urine osmolarity values were 250 and 357 mOsm/kg, respectively; these findings were consistent with SIADH. Hypertonic saline infusion and fluid restriction (<1 L/day) were continued for four days with the aim of achieving a desired serum sodium concentration of 130 meq/L. On day 26 of linezolid therapy, the drug was discontinued due to development of progressive anemia (hemoglobin concentration, 6.7 g/dL). The next day, the patient's serum sodium concentration increased abruptly to 135 meq/L and remained stable until hospital discharge. After multiple alternative etiologies were excluded, drug-induced SIADH due to linezolid use was determined to be the most likely diagnosis. Using the adverse drug reaction probability scale of Naranjo et al., the case was assigned a score of 6, indicating a probable association between linezolid use and SIADH. Conclusion. SIADH was observed in a woman who was administered linezolid for more than three weeks, with concurrent development of progressive severe anemia associated with linezolid toxicity. The patient's hyponatremia resolved after cessation of linezolid use.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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