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Can Prostate-Specific Antigen Kinetics before Prostate Biopsy Predict the Malignant Potential of Prostate Cancer?

Authors
Kim, Sang JinJeong, Tae YoongYoo, Dae SeonPark, JinsungCho, SeokKang, Seok HoLee, Sang HyubJeon, Seung HyunLee, Tchun YongPark, Sung Yul
Issue Date
1-11월-2015
Publisher
YONSEI UNIV COLL MEDICINE
Keywords
Prostate-specific antigen; prostate neoplasms; Gleason score
Citation
YONSEI MEDICAL JOURNAL, v.56, no.6, pp.1492 - 1496
Indexed
SCIE
SCOPUS
KCI
Journal Title
YONSEI MEDICAL JOURNAL
Volume
56
Number
6
Start Page
1492
End Page
1496
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/91955
DOI
10.3349/ymj.2015.56.6.1492
ISSN
0513-5796
Abstract
Purpose: To predict the malignant potential of prostate cancer (PCa) according to prostate-specific antigen velocity (PSAV), PSA density (PSAD), free/total PSA ratio (%fPSA), and digital rectal examination (DRE). Materials and Methods: From January 2009 to December 2012, 548 adult male patients were diagnosed with PCa by prostate biopsy at four hospitals in Korea. We retrospectively analyzed 155 adult male patients with an initial PSA level <= 10 ng/mL and whose PSA levels had been checked more than two times at least 6 months before they had been diagnosed with PCa, with test intervals of more than 3 months. Patients with a urinary tract infection, and patients who had previously undergone cystoscopy or surgery of the prostate were excluded. We separated patients into two groups according to Gleason sum [Gleason sum <= 7 (n=134) or Gleason sum >= 8 (n=21)] and the presence of extracapsular invasion [organ confined (n=129) or extracapsular invasion (n=26)]. Differences between the groups were compared. Results: The group with a Gleason sum >= 8 or extracapsular invasion of PCa showed high PSAV and significantly lower %fPSA. There were no significant differences in PSAD and the presence of an abnormality on DRE between two groups. Conclusion: In PCa patients treated with other therapies besides prostatectomy, a high PSA velocity and a low %fPSA may predict high grade PCa with a Gleason sum >= 8 or the presence of extracapsular invasion.
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