Interatrial septal thickness as a marker of structural and functional remodeling of the left atrium in patients with atrial fibrillation
- Authors
- Lim, Hong Euy; Na, Jin Oh; Im, Sung Il; Choi, Cheol Ung; Kim, Seong Hwan; Kim, Jin Won; Kim, Eung Ju; Han, Seong Woo; Rha, Seung-Woon; Park, Chang Gyu; Seo, Hong Seog; Oh, Dong Joo; Hwang, Chun
- Issue Date
- Nov-2015
- Publisher
- KOREAN ASSOC INTERNAL MEDICINE
- Keywords
- Atrial fibrillation; Atrial septum; Heart atria; Atrial remodeling
- Citation
- KOREAN JOURNAL OF INTERNAL MEDICINE, v.30, no.6, pp.808 - 820
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF INTERNAL MEDICINE
- Volume
- 30
- Number
- 6
- Start Page
- 808
- End Page
- 820
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/91974
- DOI
- 10.3904/kjim.2015.30.6.808
- ISSN
- 1226-3303
- Abstract
- Background/Aims: There have been reports that interatrial septal (IAS) thickness is increased in patients with atrial fibrillation (AF). This study was performed to investigate whether IAS thickness determined by transthoracic echocardiography (TTE) represents the amount of left atrium (LA) structural and functional remodeling. Methods: The study population consisted of 104 consecutive patients who underwent catheter ablation (CA) for AF (paroxysmal atrial fibrillation [PAF], 82; persistent atrial fibrillation [PeAF], 22). IAS thickness and left atrium volume (LAV) using TTE, and LA voltage (LA(VOL)) using 3-dimensional electroanatomical mapping system were assessed during sinus rhythm. Results: IAS thickness was significantly correlated with maximal LAV (LAV(max)) (r = 0.288, p = 0.003), mean LA(VOL) (r = -0.537, p < 0.001), total left atrium emptying fraction (LAEF(total); r = -0.213, p = 0.030), and active LAEF (LAEF(active); r = -0.249, p = 0.014). IAS thickness was greater in the high-risk group (>= 2) compared to other groups according to CHA(2)DS(2)-VASc score (p = 0.019). During a follow-up of 19.6 months, 23 subjects (22.1%; PAF, 17; PeAF, 6) had recurrence of arrhythmia. Univariate analysis showed that LAV(max), minimal LAV, mean LA(VOL), LVEFtotal, LVEFactive, and IAS thickness were associated with recurrence of arrhythmia. However, on multivariate analysis, only mean LAVOL and LAEFactive were independent risk factors for recurrence. Conclusions: Although IAS thickness showed significant correlations with parameters for LA structural and functional remodeling, this parameter alone could not independently predict recurrence of arrhythmia after CA for AF.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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