Paclitaxel suppresses the viability of breast tumor MCF7 cells through the regulation of EF1 alpha and FOXO3a by AMPK signaling
DC Field | Value | Language |
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dc.contributor.author | Kim, Ji Hae | - |
dc.contributor.author | Lee, Jung Ok | - |
dc.contributor.author | Kim, Nami | - |
dc.contributor.author | Lee, Hye Jeong | - |
dc.contributor.author | Lee, Yong Woo | - |
dc.contributor.author | Kim, Hyung Ip | - |
dc.contributor.author | Kim, Su Jin | - |
dc.contributor.author | Park, Sun Hwa | - |
dc.contributor.author | Kim, Hyeon Soo | - |
dc.date.accessioned | 2021-09-04T10:54:25Z | - |
dc.date.available | 2021-09-04T10:54:25Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/91986 | - |
dc.description.abstract | Paclitaxel (Taxol), a potent drug of natural origin isolated from the bark of the Pacific yew, is widely used for treating ovarian, lung and breast cancers. Currently, there is little information regarding the specific mechanism underlying the anticancer activity of paclitaxel. In the present study, we found that 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide (AICAR), a well-known activator of adenosine monophosphate (AMP)-activated protein kinase (AMPK), downregulated the protein and mRNA levels of elongation factor 1 alpha (EF1 alpha) in breast cancer MCF7 cells. Paclitaxel increased the phosphorylation of AMPK and also downregulated the expression of EF1 alpha in MCF7 cells. In addition, paclitaxel increased the expression, as well as the phosphorylation of forkhead box O3a (FOXO3a). Phosphorylation of FOXO3a was suppressed in the presence of compound C, a specific AMPK inhibitor, suggesting the involvement of AMPK in paclitaxel-induced FOXO3a phosphorylation. The induction and phosphorylation of FOXO3a by paclitaxel were not observed in EF1 alpha and AMPK knockdown cells: Co-treatment with AICAR resulted in increased susceptibility of cancer cells to paclitaxel-induced suppression of their viability and further enhanced paclitaxel-induced FOXO3a phosphorylation. These results suggest that the antitumor effects of paclitaxel in breast cancer are mediated by activation of the AMPK/EF1 alpha/FOXO3a signaling pathway. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | FORKHEAD TRANSCRIPTION FACTOR | - |
dc.subject | ACTIVATED PROTEIN-KINASE | - |
dc.subject | H-RAS P21 | - |
dc.subject | ELONGATION FACTOR-1-ALPHA | - |
dc.subject | LIFE-SPAN | - |
dc.subject | CAENORHABDITIS-ELEGANS | - |
dc.subject | SKELETAL-MUSCLE | - |
dc.subject | FAMILY-MEMBER | - |
dc.subject | ENERGY STATUS | - |
dc.subject | AMINO-ACIDS | - |
dc.title | Paclitaxel suppresses the viability of breast tumor MCF7 cells through the regulation of EF1 alpha and FOXO3a by AMPK signaling | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Su Jin | - |
dc.contributor.affiliatedAuthor | Park, Sun Hwa | - |
dc.contributor.affiliatedAuthor | Kim, Hyeon Soo | - |
dc.identifier.doi | 10.3892/ijo.2015.3153 | - |
dc.identifier.scopusid | 2-s2.0-84942875532 | - |
dc.identifier.wosid | 000363355900028 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF ONCOLOGY, v.47, no.5, pp.1874 - 1880 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
dc.citation.volume | 47 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1874 | - |
dc.citation.endPage | 1880 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | FAMILY-MEMBER | - |
dc.subject.keywordPlus | ENERGY STATUS | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.subject.keywordPlus | FORKHEAD TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | H-RAS P21 | - |
dc.subject.keywordPlus | ELONGATION FACTOR-1-ALPHA | - |
dc.subject.keywordPlus | LIFE-SPAN | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordAuthor | adenosine monophosphate-activated protein kinase | - |
dc.subject.keywordAuthor | elongation factor 1 alpha | - |
dc.subject.keywordAuthor | forkhead box O3a | - |
dc.subject.keywordAuthor | Taxol | - |
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