IL-33 induces Egr-1-dependent TSLP expression via the MAPK pathways in human keratinocytes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryu, Woo-In | - |
dc.contributor.author | Lee, Hana | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Bae, Hyun Cheol | - |
dc.contributor.author | Ryu, Hwa Jung | - |
dc.contributor.author | Son, Sang Wook | - |
dc.date.accessioned | 2021-09-04T10:55:08Z | - |
dc.date.available | 2021-09-04T10:55:08Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 0906-6705 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/91991 | - |
dc.description.abstract | Atopic dermatitis (AD) is a chronic inflammatory skin disease in which T-helper type 2 (Th2)-type immune responses are dominant. Th2 cytokine, interleukin (IL)-33 and thymic stromal lymphopoietin (TSLP) have been suggested to have an important role in AD. IL-33 is highly expressed in AD, but its role in AD has not yet been fully understood. To further identify the role of IL-33 in AD, we investigated the expression of TSLP induced by IL-33 in keratinocytes. This study revealed that IL-33 induced TSLP expression in human keratinocytes. Early growth response protein 1 (Egr)-1, which is an inflammatory transcriptional factor, is induced by IL-33. IL-33-mediated TSLP induction in keratinocytes was suppressed by treatment with mitogen-activated protein kinase (MAPK) inhibitors or small interfering RNA against Egr-1. Chromatin immunoprecipitation (ChIP) assay indicated the direct involvement of Egr-1 in IL-33-mediated TSLP induction. Taken together, these findings indicate that IL-33 may increase TSLP expression through an Egr-1-dependent mechanism via ERK1/2, JNK and p38 activation in keratinocytes. These data suggest that the IL-33-ERK/JNK/p38/Egr-1/TSLP axis is involved in allergic skin Th2 inflammation, and it may be a novel therapeutic target. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | GROWTH RESPONSE-1 EGR-1 | - |
dc.subject | ATOPIC-DERMATITIS | - |
dc.subject | T-CELLS | - |
dc.subject | ST2 | - |
dc.subject | EARLY-GROWTH-RESPONSE-1 | - |
dc.subject | INTERLEUKIN-33 | - |
dc.subject | INFLAMMATION | - |
dc.subject | MODULATION | - |
dc.subject | CYTOKINE | - |
dc.subject | INNATE | - |
dc.title | IL-33 induces Egr-1-dependent TSLP expression via the MAPK pathways in human keratinocytes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Ryu, Hwa Jung | - |
dc.contributor.affiliatedAuthor | Son, Sang Wook | - |
dc.identifier.doi | 10.1111/exd.12788 | - |
dc.identifier.scopusid | 2-s2.0-84983161305 | - |
dc.identifier.wosid | 000365404300010 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL DERMATOLOGY, v.24, no.11, pp.857 - 863 | - |
dc.relation.isPartOf | EXPERIMENTAL DERMATOLOGY | - |
dc.citation.title | EXPERIMENTAL DERMATOLOGY | - |
dc.citation.volume | 24 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 857 | - |
dc.citation.endPage | 863 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | GROWTH RESPONSE-1 EGR-1 | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | ST2 | - |
dc.subject.keywordPlus | EARLY-GROWTH-RESPONSE-1 | - |
dc.subject.keywordPlus | INTERLEUKIN-33 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordAuthor | atopic dermatitis | - |
dc.subject.keywordAuthor | early growth response protein 1 | - |
dc.subject.keywordAuthor | interleukin-33 | - |
dc.subject.keywordAuthor | mitogen-activated protein kinase | - |
dc.subject.keywordAuthor | thymic stromal lymphopoietin | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.