Obstructive sleep apnea with excessive daytime sleepiness is associated with non-alcoholic fatty liver disease regardless of visceral fat
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, Ji Hee | - |
dc.contributor.author | Ahn, Jae Hee | - |
dc.contributor.author | Yoo, Hye Jin | - |
dc.contributor.author | Seo, Ji A. | - |
dc.contributor.author | Kim, Sin Gon | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.contributor.author | Choi, Dong Seop | - |
dc.contributor.author | Shin, Chol | - |
dc.contributor.author | Kim, Nan Hee | - |
dc.date.accessioned | 2021-09-04T10:56:39Z | - |
dc.date.available | 2021-09-04T10:56:39Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92001 | - |
dc.description.abstract | Background/Aims: Obstructive sleep apnea (OSA) is associated with an increased risk of obesity and non-alcoholic fatty liver disease (NAFLD), but it remains unclear whether the risk of NAFLD is independently related to OSA regardless of visceral obesity. Thus, the aim of the present study was to examine whether OSA alone or in combination with excessive daytime sleepiness (EDS) or short sleep duration was associated with NAFLD independent of visceral fat in Korean adults. Methods: A total of 621 participants were selected from the Korean Genome and Epidemiology Study (KoGES). The abdominal visceral fat area (VFA) and hepatic fat components of the participants were assessed using computed tomography scans and they were then categorized into four groups depending on the presence of OSA and EDS. Results: The proportions of NAFLD were 21.1%, 18.5%, 32.4%, and 46.7% in participants without OSA/EDS, with only EDS, with only OSA, and with both OSA and EDS, respectively. A combination of OSA and EDS increased the odds ratio (OR) for developing NAFLD (OR, 2.75; 95% confidence interval [CI], 1.21 to 6.28) compared to those without OSA/EDS, and this association remained significant (OR, 2.38; 95% CI, 1.01 to 5.59) even after adjusting for VFA. In short sleepers (< 5 hours) with OSA, the adjusted OR for NAFLD was 2.50 (95% CI, 1.08 to 5.75) compared to those sleeping longer than 5 hours without OSA. Conclusions: In the present study, OSA was closely associated with NAFLD in Korean adults. This association was particularly strong in those with EDS or short sleep duration regardless of VFA. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ASSOC INTERNAL MEDICINE | - |
dc.subject | CHRONIC INTERMITTENT HYPOXIA | - |
dc.subject | BODY-MASS INDEX | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | HEPATIC STEATOSIS | - |
dc.subject | ASIAN-AMERICANS | - |
dc.subject | KOREAN ADULTS | - |
dc.subject | HEART HEALTH | - |
dc.subject | RISK-FACTORS | - |
dc.subject | OBESITY | - |
dc.title | Obstructive sleep apnea with excessive daytime sleepiness is associated with non-alcoholic fatty liver disease regardless of visceral fat | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yu, Ji Hee | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Jin | - |
dc.contributor.affiliatedAuthor | Seo, Ji A. | - |
dc.contributor.affiliatedAuthor | Kim, Sin Gon | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Mook | - |
dc.contributor.affiliatedAuthor | Baik, Sei Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Dong Seop | - |
dc.contributor.affiliatedAuthor | Shin, Chol | - |
dc.contributor.affiliatedAuthor | Kim, Nan Hee | - |
dc.identifier.doi | 10.3904/kjim.2015.30.6.846 | - |
dc.identifier.scopusid | 2-s2.0-84947049933 | - |
dc.identifier.wosid | 000366667300011 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF INTERNAL MEDICINE, v.30, no.6, pp.846 - 855 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.title | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.volume | 30 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 846 | - |
dc.citation.endPage | 855 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002047494 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | CHRONIC INTERMITTENT HYPOXIA | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | HEPATIC STEATOSIS | - |
dc.subject.keywordPlus | ASIAN-AMERICANS | - |
dc.subject.keywordPlus | KOREAN ADULTS | - |
dc.subject.keywordPlus | HEART HEALTH | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordAuthor | Sleep apnea, obstructive | - |
dc.subject.keywordAuthor | Fatty liver | - |
dc.subject.keywordAuthor | Intra-abdominal fat | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.