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Mechanisms of Glucocorticoid Action in Chronic Rhinosinusitis
- Authors
- Lee, Sang Hag
- Issue Date
- 11월-2015
- Publisher
- KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
- Keywords
- Chronic rhinosinusitis; glucocorticoids; glucocorticoid receptor; cytokines
- Citation
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.7, no.6, pp.534 - 537
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
- Volume
- 7
- Number
- 6
- Start Page
- 534
- End Page
- 537
- ISSN
- 2092-7355
- Abstract
- The innate immune system and its complex interplay with the adaptive immune system are increasingly being recognized as important factors in the pathogenesis of chronic rhinosinusitis (CRS). Adaptive immune components, including resident and inflammatory cells, and their associated mediators, have been the subject of most research in CRS. For this reason, theories of CRS pathogenesis have involved the concept that inflammation, rather than infection, is the dominant etiologic factor in CRS. Therefore, glucocorticoids are increasingly used to treat CRS. This review will outline our current knowledge of action mode of glucocorticoids in CRS.
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