Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Preoperative Chronic Kidney Disease Status is an Independent Prognostic Factor in Patients with Renal Cell Carcinoma

Authors
Kim, Young-WonKim, Won TaeYun, Seok JoongLee, Sang-CheolKim, Wun-JaeHa, Yun-SokPark, Yong HyunKang, Seok HoHong, Sung-HooKwon, Tae GyunByun, Seok-SooKwak, CheolKim, Yong-June
Issue Date
11월-2015
Publisher
SPRINGER
Citation
ANNALS OF SURGICAL ONCOLOGY, v.22, no.12, pp.4098 - 4103
Indexed
SCIE
SCOPUS
Journal Title
ANNALS OF SURGICAL ONCOLOGY
Volume
22
Number
12
Start Page
4098
End Page
4103
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/92063
DOI
10.1245/s10434-015-4444-0
ISSN
1068-9265
Abstract
Preoperative chronic kidney disease (CKD) status may affect disease outcomes in patients with renal cell carcinoma (RCC). This study evaluated the influence of preoperative CKD status on clinicopathological features and prognosis in patients with RCC. Between 1999 and 2011, a total of 1855 patients underwent radical nephrectomy at various centers throughout Korea. Of these patients, 1655 had an estimated glomerular filtration rate (eGFR) a parts per thousand yen60 ml/min/1.73 m(2) (non-CKD group) and 200 patients had an eGFR a parts per thousand yen30 but < 60 ml/min/1.73 m(2) (CKD group). To reduce the effects of selection bias and potential confounding factors, 600 patients in the non-CKD group were selected by propensity-score matching. The median age of all patients was 57.3 years (range 20-94 years) and the median follow-up was 35.0 months (range 1-154 months). Comparisons of the propensity-score-matched cohorts showed that T and N stages were more advanced and tumor size was larger in the CKD group than in the non-CKD group (p < 0.05 each). Kaplan-Meier analyses showed that recurrence-free survival, cancer-specific survival (CSS), and overall survival (OS) were significantly lower in the CKD group (p < 0.01 each). Multivariate regression analysis showed that preoperative CKD status was an independent predictor of CSS and OS in patients with RCC (p < 0.05 each). Preoperative CKD may be associated with more aggressive features and poorer prognosis in patients with RCC. RCC patients with preoperative CKD should be carefully and frequently followed-up after nephrectomy.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kang, Seok Ho photo

Kang, Seok Ho
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE