Efficacy of chlorhexidine bathing for reducing healthcare associated bloodstream infections: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Choi, Eun Young | - |
dc.contributor.author | Park, Dong-Ah | - |
dc.contributor.author | Kim, Hyun Jung | - |
dc.contributor.author | Park, Jinkyeong | - |
dc.date.accessioned | 2021-09-04T11:40:18Z | - |
dc.date.available | 2021-09-04T11:40:18Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2015-10-07 | - |
dc.identifier.issn | 2110-5820 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92207 | - |
dc.description.abstract | Background: We performed a meta-analysis of randomized controlled trials (RCTs) to determine if daily bathing with chlorhexidine decreased hospital-acquired BSIs in critically ill patients. Methods: We searched the MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases to identify randomized controlled trials that compared daily bathing with chlorhexidine and a control in critically ill patients. Results: This meta-analysis included five RCTs. The overall incidence of measured hospital-acquired BSIs was significantly lower in the chlorhexidine group compared to the controls 0.69 (95 % CI 0.55-0.85; P < 0.001; I-2 = 57.7 %). Gram-positive-induced (RR = 0.49, 95 % CI 0.41-0.58; P = 0.000; I-2 = 0.0 %) bacteremias were significantly less common in the chlorhexidine group. The incidence of MRSA bacteremias (RR 0.63; 95 % CI 0.44-0.91; P = 0.006; I-2 = 30.3 %) was significantly lower among patients who received mupirocin in addition to chlorhexidine bathing than among those who did not routinely receive mupirocin. Conclusions: Daily bathing with chlorhexidine may be effective to reduce the incidence of hospital-acquired BSIs. However, chlorhexidine bathing alone may be of limited utility in reduction of MRSA bacteremia; intranasal mupirocin may also be required. This meta-analysis has several limitations. Future large-scale international multicenter studies are needed. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | RESISTANT STAPHYLOCOCCUS-AUREUS | - |
dc.subject | CRITICALLY-ILL PATIENTS | - |
dc.subject | ACQUIRED INFECTIONS | - |
dc.subject | UNITS | - |
dc.subject | COLONIZATION | - |
dc.subject | TRANSMISSION | - |
dc.subject | PREVENTION | - |
dc.subject | GLUCONATE | - |
dc.subject | BACTERIA | - |
dc.subject | MRSA | - |
dc.title | Efficacy of chlorhexidine bathing for reducing healthcare associated bloodstream infections: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Jung | - |
dc.identifier.doi | 10.1186/s13613-015-0073-9 | - |
dc.identifier.scopusid | 2-s2.0-84943237312 | - |
dc.identifier.wosid | 000367392200001 | - |
dc.identifier.bibliographicCitation | ANNALS OF INTENSIVE CARE, v.5 | - |
dc.relation.isPartOf | ANNALS OF INTENSIVE CARE | - |
dc.citation.title | ANNALS OF INTENSIVE CARE | - |
dc.citation.volume | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Critical Care Medicine | - |
dc.subject.keywordPlus | RESISTANT STAPHYLOCOCCUS-AUREUS | - |
dc.subject.keywordPlus | CRITICALLY-ILL PATIENTS | - |
dc.subject.keywordPlus | ACQUIRED INFECTIONS | - |
dc.subject.keywordPlus | UNITS | - |
dc.subject.keywordPlus | COLONIZATION | - |
dc.subject.keywordPlus | TRANSMISSION | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | GLUCONATE | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | MRSA | - |
dc.subject.keywordAuthor | Chlorhexidine | - |
dc.subject.keywordAuthor | Mupirocin | - |
dc.subject.keywordAuthor | MRSA | - |
dc.subject.keywordAuthor | Critically ill | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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