Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species
DC Field | Value | Language |
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dc.contributor.author | Yu, Suyeun | - |
dc.contributor.author | Jang, Yeogil | - |
dc.contributor.author | Paik, Donggi | - |
dc.contributor.author | Lee, Eunil | - |
dc.contributor.author | Park, Joong-Jean | - |
dc.date.accessioned | 2021-09-04T11:46:15Z | - |
dc.date.available | 2021-09-04T11:46:15Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2015-10-02 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92217 | - |
dc.description.abstract | NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahYdrofolate cyclohydrolase (NMDMC) is a bifunctional enzyme involved in folate-dependent metabolism and highly expressed in rapidly proliferating cells. However, Nmdmc physiological roles remain unveiled. We found that ubiquitous Nmdmc overexpression enhanced Drosophila lifespan and stress resistance. Interestingly, Nmdmc overexpression in the fat body was sufficient to increase lifespan and tolerance against oxidative stress. In addition, these conditions coincided with significant decreases in the levels of mitochondrial ROS and Hsp22 as well as with a significant increase in the copy number of mitochondrial DNA. These results suggest that Nmdmc overexpression should be beneficial for mitochondrial homeostasis and increasing lifespan. (C) 2015 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | DEPENDENT METHYLENETETRAHYDROFOLATE DEHYDROGENASE | - |
dc.subject | CYTOCHROME-C-OXIDASE | - |
dc.subject | METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE | - |
dc.subject | ELECTRON-TRANSPORT | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | DNA-DAMAGE | - |
dc.subject | MELANOGASTER | - |
dc.subject | RESISTANCE | - |
dc.subject | SYNTHETASE | - |
dc.title | Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Eunil | - |
dc.contributor.affiliatedAuthor | Park, Joong-Jean | - |
dc.identifier.doi | 10.1016/j.bbrc.2015.08.098 | - |
dc.identifier.scopusid | 2-s2.0-84941317162 | - |
dc.identifier.wosid | 000361782500030 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.465, no.4, pp.845 - 850 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 465 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 845 | - |
dc.citation.endPage | 850 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | DEPENDENT METHYLENETETRAHYDROFOLATE DEHYDROGENASE | - |
dc.subject.keywordPlus | CYTOCHROME-C-OXIDASE | - |
dc.subject.keywordPlus | METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE | - |
dc.subject.keywordPlus | ELECTRON-TRANSPORT | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | MELANOGASTER | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | SYNTHETASE | - |
dc.subject.keywordAuthor | NMDMC | - |
dc.subject.keywordAuthor | Drosophila | - |
dc.subject.keywordAuthor | Longevity | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Mitochondrial DNA | - |
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