Effect of bone marrow-derived stem cells and bone morphogenetic protein-2 on treatment of osteoradionecrosis in a rat model
DC Field | Value | Language |
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dc.contributor.author | Jin, Im Geon | - |
dc.contributor.author | Kim, Jin Ho | - |
dc.contributor.author | Wu, Hong-Gyun | - |
dc.contributor.author | Kim, Sook Kyoung | - |
dc.contributor.author | Park, Yongdoo | - |
dc.contributor.author | Hwang, Soon Jung | - |
dc.date.accessioned | 2021-09-04T11:56:03Z | - |
dc.date.available | 2021-09-04T11:56:03Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 1010-5182 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92288 | - |
dc.description.abstract | Purpose: We investigated the effect of rat mesenchymal stem cells (rMSCs) and bone morphogenetic protein-2 (BMP-2) on the osseous healing of osteoradionecrosis in the rat mandible, depending on application time. Material and methods: One week after irradiation (30 Gy) on the right mandible, all molar teeth were extracted. In Group 1 (n = 25), rMSCs and/or BMP-2 carried with hydrogel were applied immediately after surgery. In Group 2 (n = 25), application was done 4 weeks after surgery, after the occurrence of osteoradionecrosis. No hydrogel (n = 5), hydrogel alone (n = 5), hydrogel with 2 x 10(4) rMSCs (n = 5), hydrogel with 10 mu g of BMP-2 (n = 5), or hydrogel with 10 mu g of BMP-2 and 2 x 10(4) rMSCs (n = 5) was applied. Micro-CT data of bone healing were collected at 4 weeks post-application. Results: In Group 1, BMP-2 was effective in increasing both bone volume (BV) and bone mineral density (BMD), whereas rMSCs were not. In Group 2, the combined application of rMSCs and BMP-2 significantly increased BMD and BV compared to values in the groups without hydrogel and with hydrogel alone. Conclusion: Osseous healing after post-irradiation trauma in rats was enhanced immediately after dentoalveolar trauma by application of BMP-2, whereas the combined application of rMSCs and BMP-2 was most effective after osteoradionecrosis occurred. (C) 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CHURCHILL LIVINGSTONE | - |
dc.subject | ACID-BASED HYDROGELS | - |
dc.subject | STROMAL CELLS | - |
dc.subject | IN-VIVO | - |
dc.subject | REGENERATION | - |
dc.subject | REPAIR | - |
dc.subject | TISSUE | - |
dc.subject | BMP-2 | - |
dc.subject | RADIATION | - |
dc.subject | HEAD | - |
dc.subject | DIFFERENTIATION | - |
dc.title | Effect of bone marrow-derived stem cells and bone morphogenetic protein-2 on treatment of osteoradionecrosis in a rat model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sook Kyoung | - |
dc.contributor.affiliatedAuthor | Park, Yongdoo | - |
dc.identifier.doi | 10.1016/j.jcms.2015.06.035 | - |
dc.identifier.scopusid | 2-s2.0-84941939270 | - |
dc.identifier.wosid | 000362604000025 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, v.43, no.8, pp.1478 - 1486 | - |
dc.relation.isPartOf | JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY | - |
dc.citation.title | JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY | - |
dc.citation.volume | 43 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1478 | - |
dc.citation.endPage | 1486 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dentistry, Oral Surgery & Medicine | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Dentistry, Oral Surgery & Medicine | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | ACID-BASED HYDROGELS | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | BMP-2 | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordPlus | HEAD | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordAuthor | Bone marrow-derived stem cell | - |
dc.subject.keywordAuthor | Bone morphogenetic protein-2 | - |
dc.subject.keywordAuthor | Osteoradionecrosis | - |
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