Associations between the functional CD40 rs4810485 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Y. H. | - |
dc.contributor.author | Bae, S-C | - |
dc.contributor.author | Choi, S. J. | - |
dc.contributor.author | Ji, J. D. | - |
dc.contributor.author | Song, G. G. | - |
dc.date.accessioned | 2021-09-04T12:03:26Z | - |
dc.date.available | 2021-09-04T12:03:26Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92346 | - |
dc.description.abstract | Objective: The aim of this study was to determine whether the functional CD40 rs4810485 G/T polymorphism is associated with susceptibility to rheumatoid arthritis (RA) or with susceptibility to systemic lupus erythematosus (SLE). Methods: A series of meta-analyses were conducted to test for association between the CD40 rs4810485 G/T polymorphism and RA or SLE. Results: A total of 21 comparisons involving 15,095 patients and 27,050 controls for RA, and 1353 patients and 2342 controls for SLE were considered. Meta-analysis showed a significant association between the CD40 rs4810485 T allele and RA in all subjects (odds ratio (OR) 0.890, 95% confidence interval (CI) 0.846-0.936, p = 5.5 x 10(-7)). After stratification by ethnicity, the CD40 T allele was found to be significantly associated with RA in Europeans (OR 0.879, 95% CI 0.848-0.901, p = 3.0 x 10(-9)). A similar pattern of association was observed between the CD40 T allele and RA when the analysis was performed using the recessive, dominant, and additive models. Meta-analysis also showed a significant association between the CD40 polymorphism and SLE in Europeans (OR for the T allele 0.715, 95% CI 0.641-0.832, p = 1.4 x 10(-6)). Conclusions: Our meta-analyses confirm that the CD40 rs4810485 G/T polymorphism is associated with susceptibility to RA and SLE in Europeans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | GENOME SCAN METAANALYSIS | - |
dc.subject | CLINICAL-MANIFESTATIONS | - |
dc.subject | POPULATIONS | - |
dc.subject | EXPRESSION | - |
dc.subject | DISEASE | - |
dc.subject | REGION | - |
dc.subject | COHORT | - |
dc.subject | LIGAND | - |
dc.subject | ITGAM | - |
dc.subject | RISK | - |
dc.title | Associations between the functional CD40 rs4810485 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.identifier.doi | 10.1177/0961203315583543 | - |
dc.identifier.scopusid | 2-s2.0-84941198406 | - |
dc.identifier.wosid | 000361071500007 | - |
dc.identifier.bibliographicCitation | LUPUS, v.24, no.11, pp.1177 - 1183 | - |
dc.relation.isPartOf | LUPUS | - |
dc.citation.title | LUPUS | - |
dc.citation.volume | 24 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1177 | - |
dc.citation.endPage | 1183 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | GENOME SCAN METAANALYSIS | - |
dc.subject.keywordPlus | CLINICAL-MANIFESTATIONS | - |
dc.subject.keywordPlus | POPULATIONS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | REGION | - |
dc.subject.keywordPlus | COHORT | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | ITGAM | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | systemic lupus erythematosus | - |
dc.subject.keywordAuthor | CD40 | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | meta-analysis | - |
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