eNOS3 Genetic Polymorphism Is Related to Post-Ablation Early Recurrence of Atrial Fibrillation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shim, Jaemin | - |
dc.contributor.author | Park, Jae Hyung | - |
dc.contributor.author | Lee, Ji-Young | - |
dc.contributor.author | Uhm, Jae-Sun | - |
dc.contributor.author | Joung, Boyoung | - |
dc.contributor.author | Lee, Moon-Hyoung | - |
dc.contributor.author | Ellinoe, Patrick T. | - |
dc.contributor.author | Pak, Hui-Nam | - |
dc.date.accessioned | 2021-09-04T12:52:43Z | - |
dc.date.available | 2021-09-04T12:52:43Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-09-01 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92518 | - |
dc.description.abstract | Purpose: Previous studies have demonstrated an association between eNOS polymorphisms and atrial fibrillation (AF). We sought to determine whether eNOS polymorphisms are associated with AF recurrence after a radiofrequency catheter ablation (RFCA). Materials and Methods: A total of 500 consecutive patients (56 +/- 11 years, 77% male) with paroxysmal (68%) or persistent (32%) AF who underwent RFCA and 500 age, gender-matched controls were genotyped for the eNOS3 single nucleotide polymorphism (rs1799983). AF recurrence was monitored according to 2012 ACC/AHA/ESC guidelines. Results: The frequencies of the rsI799983 variant alleles (T) in the case and control group were not significantly different (OR 1.05, 95% CI 0.75-1.46, p=0.798). AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004). During mean 17 months follow-up, early recurrence of AF (ERAF; within 3 months) and clinical recurrence (CR) of AF were 31.8% and 24.8%, respectively. The rsI799983 variant was associated with higher risk of ERAF (OR 1.71, 95% CI 1.06-2.79, p=0.028), but not with CR. ERAF occurred earlier (11 +/- 16 days) in variant group than those without variant allele (20 +/- 25 days, p=0.016). A multiple logistic regression analysis showed that presence of the rs1799983 variant (OR 1.75, 95% CI 1.07-2.86, p=0.026) and persistent AF were independent predictors for ERAF after AF ablation. Conclusion: The rs1799983 variant of the eNOS3 gene was associated with ERAF, but not with CR, after RFCA. eNOS3 gene variants may have a potential role for stratification of post-ablation management. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.subject | RADIOFREQUENCY CATHETER ABLATION | - |
dc.subject | C-REACTIVE PROTEIN | - |
dc.subject | ELECTROGRAMS | - |
dc.subject | ASSOCIATION | - |
dc.subject | HYPERTENSION | - |
dc.subject | MECHANISMS | - |
dc.subject | ELEVATION | - |
dc.subject | DURATION | - |
dc.subject | RISK | - |
dc.title | eNOS3 Genetic Polymorphism Is Related to Post-Ablation Early Recurrence of Atrial Fibrillation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shim, Jaemin | - |
dc.identifier.doi | 10.3349/ymj.2015.56.5.1244 | - |
dc.identifier.scopusid | 2-s2.0-84938894952 | - |
dc.identifier.wosid | 000359886200011 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.56, no.5, pp.1244 - 1250 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 56 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1244 | - |
dc.citation.endPage | 1250 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002022002 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | RADIOFREQUENCY CATHETER ABLATION | - |
dc.subject.keywordPlus | C-REACTIVE PROTEIN | - |
dc.subject.keywordPlus | ELECTROGRAMS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | HYPERTENSION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | ELEVATION | - |
dc.subject.keywordPlus | DURATION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Atrial fibrillation | - |
dc.subject.keywordAuthor | eNOS gene | - |
dc.subject.keywordAuthor | catheter ablation | - |
dc.subject.keywordAuthor | recurrence | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.