The neuroprotective effect of magnesium sulfate in preterm fetal mice
DC Field | Value | Language |
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dc.contributor.author | Cho, Geum Joon | - |
dc.contributor.author | Hong, Hye-Ri | - |
dc.contributor.author | Hong, Soon-Cheol | - |
dc.contributor.author | Oh, Min-Jeong | - |
dc.contributor.author | Kim, Hai-Joong | - |
dc.date.accessioned | 2021-09-04T13:03:27Z | - |
dc.date.available | 2021-09-04T13:03:27Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 0300-5577 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92600 | - |
dc.description.abstract | Objective: To investigate the use of magnesium sulfate (MgSO4) as a neuroprotective agent in a mouse model of inflammation-associated and noninflammation-associated preterm birth. Methods: On embryonic day 15 of gestation, lipopolysaccharide (LPS) and mifepristone (RU486) were used, respectively, to create mouse models of inflammation and noninflammation-associated preterm birth. After intraperitoneal injection of LPS, RU486, or normal saline solution (NS), dams were randomized to intraperitoneal MgSO4 or NS injection. From the 6 treatment groups (NS+NS, LPS+NS, NS+MgSO4, LPS+MgSO4, RU486+NS and RU486+MgSO4), fetal brains were collected for Western blot analysis and neuronal cultures. Protein expression of S100B was assessed, and immunohistochemistry was performed to detect NeuN. The numbers of NeuN-labeled cells were counted using confocal laser scanning microscopy. Results: The expression of S100B significantly differed among the groups and was decreased in the LPS+MgSO4 group compared to the LPS+NS group. The expression of S100B did not differ between the RU486+NS and RU486+MgSO4 groups. NeuN-labeled cells were increased in the LPS+MgSO4 group compared with the LPS+NS group. NeuN-labeled cells were decreased in the RU486+MgSO4 group compared with the RU486+NS group. Conclusions: We observed that prenatal treatment with MgSO4 was associated with decreased expression of S100B and increased numbers of NeuN-labeled cells in an inflammation-associated preterm mouse model but not in a noninflammation-associated preterm mouse model. Our results suggest that prenatal treatment of MgSO4 reduces inflammation-associated brain injury in fetal mice. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WALTER DE GRUYTER GMBH | - |
dc.subject | URINARY S100B PROTEIN | - |
dc.subject | WHITE-MATTER INJURY | - |
dc.subject | CEREBRAL-PALSY | - |
dc.subject | INTRAVENTRICULAR HEMORRHAGE | - |
dc.subject | EARLY INDICATOR | - |
dc.subject | BRAIN-DAMAGE | - |
dc.subject | INFANTS | - |
dc.subject | BIRTH | - |
dc.subject | EXPRESSION | - |
dc.subject | PREVENTION | - |
dc.title | The neuroprotective effect of magnesium sulfate in preterm fetal mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Geum Joon | - |
dc.contributor.affiliatedAuthor | Hong, Soon-Cheol | - |
dc.contributor.affiliatedAuthor | Oh, Min-Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Hai-Joong | - |
dc.identifier.doi | 10.1515/jpm-2014-0176 | - |
dc.identifier.scopusid | 2-s2.0-84941139951 | - |
dc.identifier.wosid | 000360960600005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PERINATAL MEDICINE, v.43, no.5, pp.537 - 543 | - |
dc.relation.isPartOf | JOURNAL OF PERINATAL MEDICINE | - |
dc.citation.title | JOURNAL OF PERINATAL MEDICINE | - |
dc.citation.volume | 43 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 537 | - |
dc.citation.endPage | 543 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | URINARY S100B PROTEIN | - |
dc.subject.keywordPlus | WHITE-MATTER INJURY | - |
dc.subject.keywordPlus | CEREBRAL-PALSY | - |
dc.subject.keywordPlus | INTRAVENTRICULAR HEMORRHAGE | - |
dc.subject.keywordPlus | EARLY INDICATOR | - |
dc.subject.keywordPlus | BRAIN-DAMAGE | - |
dc.subject.keywordPlus | INFANTS | - |
dc.subject.keywordPlus | BIRTH | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordAuthor | Magnesium sulfate | - |
dc.subject.keywordAuthor | mouse | - |
dc.subject.keywordAuthor | NeuN | - |
dc.subject.keywordAuthor | preterm birth | - |
dc.subject.keywordAuthor | S100B | - |
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