Development of part-dissolvable chitosan fibers with surface N-succinylation for wound care dressing
- Authors
- Sun, Guohui; Feng, Chao; Kong, Ming; Cheng, Xiaojie; Bing, Jiaojiao; Xia, Guixue; Bao, Zixian; Park, Hyunjin; Chen, Xiguang
- Issue Date
- 9월-2015
- Publisher
- HIGHER EDUCATION PRESS
- Keywords
- chitosan fiber; surface N-succinylation; liquor absorptivity; part-dissolvability; wound dressing
- Citation
- FRONTIERS OF MATERIALS SCIENCE, v.9, no.3, pp.272 - 281
- Indexed
- SCIE
SCOPUS
- Journal Title
- FRONTIERS OF MATERIALS SCIENCE
- Volume
- 9
- Number
- 3
- Start Page
- 272
- End Page
- 281
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/92636
- DOI
- 10.1007/s11706-015-0303-y
- ISSN
- 2095-025X
- Abstract
- To enhance the liquor absorptivity of chitosan fibers (CS-Fs), N-succinyl surface-modified chitosan fibers (NSCS-Fs) were developed and evaluated for wound healing. The NSCS-Fs exhibited cracks on the surface and high liquor absorbing capacity with absorbing-dissolvable equilibrium state in phosphate buffer solution (PBS). The bacteriostasis ratios of NSCS-Fs against E. coli, S. aureus and C. albicans were higher than 80%. No cytotoxicity has been found for mouse embryo fibroblasts (MEFs) treated with NSCS-Fs leach liquor. Acute oral toxicity and skin irritation experiment were taken to evaluate the safety of NSCS-Fs in vitro. Muscle implant study showed that NSCS-Fs were biodegradable and non-toxic in vivo. These results suggested that the surface modified NSCS-Fs had favorable biological properties and improved liquor absorptivity, indicating that they could be used as promising dressing materials for wound care.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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