Toxic response of graphene nanoplatelets in vivo and in vitro
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Eun-Jung | - |
dc.contributor.author | Lee, Gwang-Hee | - |
dc.contributor.author | Han, Beom Seok | - |
dc.contributor.author | Lee, Byoung-Seok | - |
dc.contributor.author | Lee, Somin | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.contributor.author | Kim, Jae-Ho | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.date.accessioned | 2021-09-04T13:09:27Z | - |
dc.date.available | 2021-09-04T13:09:27Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 0340-5761 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92645 | - |
dc.description.abstract | With the development of nanotechnology, myriad types of novel materials have been discovered at the nanoscale, among which the most interesting material is graphene. However, the toxicity data available on graphene are extremely limited. In this study, we explored toxic response of commercially available graphene nanoplatelets (GNPs) in vivo and in vitro. The GNPs used in this study had a high surface area and feature considerably few defects. In mice, GNPs (2.5 and 5 mg/kg) remained in the lung until 28 days after a single instillation, and the secretion of inflammatory cytokines reached the maximal level at Day 14 and then decreased over time. In vitro study using BEAS-2B cells, a human bronchial epithelial cell line, GNPs located within autophagosome-like vacuoles 24 h after exposure. The GNPs (2.5, 5, 10, and 20 mu g/mL) also dose-dependently reduced cell viability, which was accompanied by an increase in the portion of cells in the subG1 and S phases. Moreover, the GNPs down-regulated the generation of reactive oxygen species, suppressed ATP production, caused mitochondria damage, and elevated the levels of autophagy-related proteins. Based on these results, we suggest that GNPs provoked a subchronic inflammatory response in mice and that GNPs induced autophagy accompanying apoptosis via mitochondria damage in vitro. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject | ELECTROLYTIC EXFOLIATION | - |
dc.subject | CARBON NANOTUBES | - |
dc.subject | CELL-DEATH | - |
dc.subject | NANOSHEETS | - |
dc.subject | GRAPHITE | - |
dc.subject | OXIDE | - |
dc.subject | PROTEIN | - |
dc.subject | INTERCALATION | - |
dc.subject | NANOPARTICLES | - |
dc.title | Toxic response of graphene nanoplatelets in vivo and in vitro | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.identifier.doi | 10.1007/s00204-014-1303-x | - |
dc.identifier.scopusid | 2-s2.0-84940579856 | - |
dc.identifier.wosid | 000360412500008 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF TOXICOLOGY, v.89, no.9, pp.1557 - 1568 | - |
dc.relation.isPartOf | ARCHIVES OF TOXICOLOGY | - |
dc.citation.title | ARCHIVES OF TOXICOLOGY | - |
dc.citation.volume | 89 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1557 | - |
dc.citation.endPage | 1568 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject.keywordPlus | ELECTROLYTIC EXFOLIATION | - |
dc.subject.keywordPlus | CARBON NANOTUBES | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | NANOSHEETS | - |
dc.subject.keywordPlus | GRAPHITE | - |
dc.subject.keywordPlus | OXIDE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | INTERCALATION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordAuthor | Graphene | - |
dc.subject.keywordAuthor | Nanoplatelets | - |
dc.subject.keywordAuthor | Toxicity | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | Mitochondria | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.