LPS Up-Regulates ICAM-1 Expression in Breast Cancer Cells by Stimulating a MyD88-BLT2-ERK-Linked Cascade, Which Promotes Adhesion to Monocytes
DC Field | Value | Language |
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dc.contributor.author | Park, Geun-Soo | - |
dc.contributor.author | Kim, Jae-Hong | - |
dc.date.accessioned | 2021-09-04T13:10:11Z | - |
dc.date.available | 2021-09-04T13:10:11Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92649 | - |
dc.description.abstract | Monocytes are the major inflammatory cells that infiltrate most solid tumors in humans. The interaction of tumor cells with infiltrating monocytes and their adhesion to these monocytes play a significant role in altering the tumor to become more aggressive. Recently, exposure to lipopolysaccharide (LPS) was suggested to promote cancer cell adhesion to monocytes; however, little is known about the details of the signaling mechanism involved in this process. In this study, we found that LPS up-regulates ICAM-1 expression in MDA-MB-231 breast cancer cells, which facilitates their adhesion to THP-1 monocytes. In addition, we analyzed the signaling mechanism underlying the up-regulation of ICAM-1 and found that the siRNA-mediated depletion of BLT2 markedly suppressed the LPS-induced expression of ICAM-1 in MDA-MB-231 cells and the subsequent adhesion of these cells to THP-1 monocytes. Moreover, we demonstrated that myeloid differentiation primary response gene 88 (MyD88) lies downstream of LPS/TLR4 and upstream of BLT2 and that this 'MyD88BLT2' cascade mediates ERK activation and subsequent ICAM-1 expression, which is critical for the adhesion of MDA-MB-231 cells to THP-1 monocytes. Taken together, our results demonstrate for the first time that LPS up-regulates ICAM-1 expression in breast cancer cells via a MyD88-BLT2-ERK-linked signaling cascade, leading to the increased adhesion of breast cancer cells to monocytes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.subject | LEUKOTRIENE B-4 RECEPTOR-2 | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | INFLAMMATION | - |
dc.subject | INVASIVENESS | - |
dc.subject | MACROPHAGES | - |
dc.subject | INVOLVEMENT | - |
dc.subject | PROGRESSION | - |
dc.subject | INVASION | - |
dc.subject | MAPKS | - |
dc.title | LPS Up-Regulates ICAM-1 Expression in Breast Cancer Cells by Stimulating a MyD88-BLT2-ERK-Linked Cascade, Which Promotes Adhesion to Monocytes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hong | - |
dc.identifier.doi | 10.14348/molcells.2015.0174 | - |
dc.identifier.scopusid | 2-s2.0-84966536006 | - |
dc.identifier.wosid | 000363381800011 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.38, no.9, pp.821 - 828 | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 38 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 821 | - |
dc.citation.endPage | 828 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002032721 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | LEUKOTRIENE B-4 RECEPTOR-2 | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | INVASIVENESS | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | MAPKS | - |
dc.subject.keywordAuthor | beast cancer | - |
dc.subject.keywordAuthor | BLT2 | - |
dc.subject.keywordAuthor | ICAM-1 | - |
dc.subject.keywordAuthor | LPS | - |
dc.subject.keywordAuthor | MyD88 | - |
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