Transduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model
DC Field | Value | Language |
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dc.contributor.author | Kim, Mi Jin | - |
dc.contributor.author | Park, Meeyoung | - |
dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Shin, Min Jea | - |
dc.contributor.author | Son, Ora | - |
dc.contributor.author | Jo, Hyo Sang | - |
dc.contributor.author | Yeo, Hyeon Ji | - |
dc.contributor.author | Cho, Su Bin | - |
dc.contributor.author | Park, Jung Hwan | - |
dc.contributor.author | Lee, Chi Hem | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.contributor.author | Kwon, Oh-Shin | - |
dc.contributor.author | Kim, Joon | - |
dc.contributor.author | Han, Kyu Hyung | - |
dc.contributor.author | Park, Jinseu | - |
dc.contributor.author | Eum, Won Sik | - |
dc.contributor.author | Choi, Soo Young | - |
dc.date.accessioned | 2021-09-04T13:12:47Z | - |
dc.date.available | 2021-09-04T13:12:47Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92665 | - |
dc.description.abstract | Parkinson's disease (PD) is an oxidative stress-mediated neurodegenerative disorder caused by selective dopaminergic neuronal death in the midbrain substantia nigra. Paraoxonase 1 (PON1) is a potent inhibitor of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) against oxidation by destroying biologically active phospholipids with potential protective effects against oxidative stress-induced inflammatory disorders. In a previous study, we constructed protein transduction domain (PTD) fusion PEP-1-PON1 protein to transduce PON1 into cells and tissue. In this study, we examined the role of transduced PEP-1-PON1 protein in repressing oxidative stress-mediated inflammatory response in microglial BV2 cells after exposure to lipopolysaccharide (LPS). Moreover, we identified the functions of transduced PEP-1-PON1 proteins which include, mitigating mitochondrial damage, decreasing reactive oxidative species (ROS) production, matrix metalloproteinase-9 (MMP-9) expression and protecting against 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in SH-SY5Y cells. Furthermore, transduced PEP-1-PON1 protein reduced MMP-9 expression and protected against dopaminergic neuronal cell death in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice model. Taken together, these results suggest a promising therapeutic application of PEP-1-PON1 proteins against PD and other inflammation and oxidative stress-related neuronal diseases. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | HIGH-DENSITY-LIPOPROTEINS | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | PARAOXONASE ACTIVITY | - |
dc.subject | EXPRESSION | - |
dc.subject | MPTP | - |
dc.subject | INFLAMMATION | - |
dc.subject | INHIBITION | - |
dc.subject | RECEPTOR | - |
dc.subject | DECREASES | - |
dc.title | Transduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Joon | - |
dc.identifier.doi | 10.1016/j.biomaterials.2015.06.015 | - |
dc.identifier.scopusid | 2-s2.0-84937439736 | - |
dc.identifier.wosid | 000358631300006 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.64, pp.45 - 56 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 64 | - |
dc.citation.startPage | 45 | - |
dc.citation.endPage | 56 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | HIGH-DENSITY-LIPOPROTEINS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | PARAOXONASE ACTIVITY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MPTP | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | DECREASES | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | PEP-1-PON1 | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Dopaminergic neuronal death | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Protein therapy | - |
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