Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

A multicenter analysis of adjuvant therapy after surgery for stage IIIC endometrial adenocarcinoma: A Korean Radiation Oncology Group study (KROG 13-17)

Authors
Yoon, Mee SunPark, WonHuh, Seung JaeKim, Hak JaeKim, Young SeokKim, Yong BaeKim, Joo-YoungLee, Jong-HoonKim, Hun JungCha, JihyeKim, Jin HeeKim, JureeYoon, Won SupChoi, Jin HwaChun, MisonChoi, YoungminChang, Sei KyungLee, Kang KyooKim, Myungsoo
Issue Date
9월-2015
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Endometrial cancer; Adjuvant radiotherapy; Adjuvant chemoradiotherapy
Citation
GYNECOLOGIC ONCOLOGY, v.138, no.3, pp.519 - 525
Indexed
SCIE
SCOPUS
Journal Title
GYNECOLOGIC ONCOLOGY
Volume
138
Number
3
Start Page
519
End Page
525
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/92671
DOI
10.1016/j.ygyno.2015.06.030
ISSN
0090-8258
Abstract
Objective. To investigate whether combined chemoradiotherapy (CTRT) confers a benefit for survival outcome over radiotherapy (RT) alone after primary surgery in patients with FIGO stage IIIC endometrial adenocarcinoma. Methods. We conducted a multicenter retrospective study of patients with surgical stage IIIC endometrial cancer from 1990 to 2011. Adjuvant RT alone was performed in 85 patients (403%) and adjuvant CTRT in 126 patients (59.7%). Disease-free survival (DFS) and overall survival (OS) were analyzed using Kaplan-Meier method and Cox proportional hazards model. Results. Stage 1110 and stage IIIC2 accounted for 63% and 37%, respectively. FIGO IIIC2 had a higher recurrence rate than FIGO IIIC1 (38.5% vs. 293%, p = 0.172). Five-year OS and DFS were lower in FIGO IIIC2 than FIGO IIIC1 (85.1% vs. 76.9%, p = 0.417; 71.0% vs. 59.2%, p = 0.108, respectively). Eighteen patients (13.5%) in stage IIIC1 developed PALN recurrence, whereas only one (3.3%) in stage IIIC2 had PALN recurrence (p = 0.001). In multivariate analysis, predictors of DFS were parametrial invasion (HR, 3.49; 95% CI, 1.83-6.64; p < 0.001), higher grade (HR, 2.78; 95% CI, 1.31-5.89; p = 0.008), and >3 positive pelvic nodes (HR, 1.84; 95% CI, 1.11-3.05; p = 0.019). Combined CTRT did not affect DFS or OS in IIIC1 and IIIC2 compared with RT alone. Conclusion. CTRT showed comparable survival outcome to RT alone. Half of relapses (46%) in stage IIIC1 occurred in PALN region, whereas relapse in stage IIIC2 primarily occurred in distant metastasis (90%). Future randomized studies are needed to determine which subgroup may be most likely to benefit from CCRT. (C) 2015 Elsevier Inc. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE