Differential Prognostic Effect Between First- and Second-Generation Drug-Eluting Stents in Coronary Bifurcation Lesions Patient-Level Analysis of the Korean Bifurcation Pooled Cohorts
DC Field | Value | Language |
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dc.contributor.author | Lee, Joo Myung | - |
dc.contributor.author | Hahn, Joo-Yong | - |
dc.contributor.author | Kang, Jeehoon | - |
dc.contributor.author | Park, Kyung Woo | - |
dc.contributor.author | Chun, Woo Jung | - |
dc.contributor.author | Rha, Seung Woon | - |
dc.contributor.author | Yu, Cheol Woong | - |
dc.contributor.author | Jeong, Jin-Ok | - |
dc.contributor.author | Jeong, Myung-Ho | - |
dc.contributor.author | Yoon, Jung Han | - |
dc.contributor.author | Jang, Yangsoo | - |
dc.contributor.author | Tahk, Seung-Jea | - |
dc.contributor.author | Gwon, Hyeon-Cheol | - |
dc.contributor.author | Koo, Bon-Kwon | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.date.accessioned | 2021-09-04T13:22:08Z | - |
dc.date.available | 2021-09-04T13:22:08Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-08-24 | - |
dc.identifier.issn | 1936-8798 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92733 | - |
dc.description.abstract | OBJECTIVES The purpose of this study was to investigate the differential clinical outcomes after percutaneous coronary intervention (PCI) for coronary bifurcation lesions with 1- or 2-stenting techniques using first-or second-generation drug-eluting stents (DES). BACKGROUND The 2-stenting technique has been regarded to have worse clinical outcomes than the 1-stenting technique after bifurcation PCI with first-generation DES. However, there has been a paucity of data comparing the 1- and 2-stenting techniques with the use of second-generation DES. METHODS Patient-level pooled analysis was performed with 3,162 patients undergoing PCI using first-or second-generation DES for bifurcation lesions from the "Korean Bifurcation Pooled Cohorts" (COBIS [Coronary Bifurcation Stenting] II, EXCELLENT [Registry to Evaluate Efficacy of Xience/Promus Versus Cypher in Reducing Late Loss After Stenting], and RESOLUTE-Korea [Registry to Evaluate the Efficacy of Zotarolimus-Eluting Stent]). The 3-year clinical outcomes were compared between 1- and 2-stenting techniques, stratified by the type of DES. RESULTS With first-generation DES, rates of target lesion failure (TLF) or patient-oriented composite outcome (POCO) (a composite of all death, any myocardial infarction, any repeat revascularization, and cerebrovascular accidents) at 3 years were significantly higher after the 2-stenting than the 1-stenting technique (TLF 8.6% vs. 17.5%; p < 0.001; POCO 18.1% vs. 28.5%, p < 0.001). With second-generation DES, however, there was no difference between 1-and 2-stenting techniques (TLF 5.4% vs. 5.8%; p = 0.768; POCO 11.2% vs. 12.9%; p = 0.995). The differential effects of 2-stenting technique on the prognosis according to the type of DES were also corroborated with similar results by the inverse probability weighted model. The 2-stenting technique was a significant independent predictor of TLF in first-generation DES (hazard ratio: 2.046; 95% confidence interval: 1.114 to 3.759; p < 0.001), but not in second-generation DES (hazard ratio: 0.667; 95% confidence interval: 0.247 to 1.802; p = 0.425). CONCLUSIONS Patient-level pooled analysis of 3,162 patients in Korean Bifurcation Pooled Cohorts demonstrated that the 2-stenting technique showed comparable outcomes to 1-stenting technique with second-generation DES, which is different from the results of first-generation DES favoring the 1-stenting technique. (C) 2015 by the American College of Cardiology Foundation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | CLINICAL-OUTCOMES | - |
dc.subject | RANDOMIZED-TRIAL | - |
dc.subject | LEFT MAIN | - |
dc.subject | INTERVENTION | - |
dc.subject | ZOTAROLIMUS | - |
dc.subject | EXCELLENT | - |
dc.subject | STRATEGY | - |
dc.subject | RESOLUTE | - |
dc.subject | CRUSH | - |
dc.title | Differential Prognostic Effect Between First- and Second-Generation Drug-Eluting Stents in Coronary Bifurcation Lesions Patient-Level Analysis of the Korean Bifurcation Pooled Cohorts | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rha, Seung Woon | - |
dc.contributor.affiliatedAuthor | Yu, Cheol Woong | - |
dc.identifier.doi | 10.1016/j.jcin.2015.05.014 | - |
dc.identifier.scopusid | 2-s2.0-84940382372 | - |
dc.identifier.wosid | 000360017500010 | - |
dc.identifier.bibliographicCitation | JACC-CARDIOVASCULAR INTERVENTIONS, v.8, no.10, pp.1318 - 1331 | - |
dc.relation.isPartOf | JACC-CARDIOVASCULAR INTERVENTIONS | - |
dc.citation.title | JACC-CARDIOVASCULAR INTERVENTIONS | - |
dc.citation.volume | 8 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1318 | - |
dc.citation.endPage | 1331 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | RANDOMIZED-TRIAL | - |
dc.subject.keywordPlus | LEFT MAIN | - |
dc.subject.keywordPlus | INTERVENTION | - |
dc.subject.keywordPlus | ZOTAROLIMUS | - |
dc.subject.keywordPlus | EXCELLENT | - |
dc.subject.keywordPlus | STRATEGY | - |
dc.subject.keywordPlus | RESOLUTE | - |
dc.subject.keywordPlus | CRUSH | - |
dc.subject.keywordAuthor | bifurcation | - |
dc.subject.keywordAuthor | clinical outcome | - |
dc.subject.keywordAuthor | coronary bifurcation lesion | - |
dc.subject.keywordAuthor | drug-eluting stent | - |
dc.subject.keywordAuthor | percutaneous coronary intervention | - |
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