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Does delayed facial involvement implicate a pattern of "descending reversible paralysis" in Fisher syndrome?

Authors
Kim, Jong KukKim, Byung-JoShin, Ha YoungShin, Kyong JinNam, Tai-SeungSeok, Jung ImSuh, Bum ChunOh, JeeyoungKim, Yeo JungBae, Jong Seok
Issue Date
8월-2015
Publisher
ELSEVIER SCIENCE BV
Keywords
Fisher syndrome; Delayed; Facial nerve; Paralysis; Pathophysiology
Citation
CLINICAL NEUROLOGY AND NEUROSURGERY, v.135, pp.1 - 5
Indexed
SCIE
SCOPUS
Journal Title
CLINICAL NEUROLOGY AND NEUROSURGERY
Volume
135
Start Page
1
End Page
5
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/92797
DOI
10.1016/j.clineuro.2015.04.025
ISSN
0303-8467
Abstract
Objective: Delayed facial palsy (DFP) has often been described during the recovery stage of Fisher syndrome (FS), but the implications of DFP in FS pathophysiology have not been reported previously. The aim of this study was to identify the incidence and clinical course of DFP in FS, and to determine its clinical/pathophysiological implications in FS. Methods: About 71 FS patients were enrolled from seven university-based hospitals in Korea. DFP was defined with respect to new development of unilateral or bilateral facial palsies with delayed onset after either the nadir or improvement of initial neurological signs of FS. Results: Eleven of the 71 patients (16%) satisfied the definition of DFP. No other cranial palsies developed as a delayed pattern. With the exception of two patients with bulbar involvement, DFP developed after a latent period of upper-cranial neuropathies. Comparison of FS patients without and with DFP revealed no significant clinical, serological, or electrophysiological differences. All except one patient with DFP exhibited a good outcome within 1 month of follow-up. Conclusion: DFP was identified as a common and specific phenomenon in FS. Nearly all cases of DFP were developed in a descending manner and were associated with a good outcome, while other cranial neuropathies developed or followed as a sequential pattern. These findings suggest the involvement of so-called "descending reversible paralysis" in the pathophysiology of FS. (C) 2015 Elsevier B.V. All rights reserved.
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