CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury
DC Field | Value | Language |
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dc.contributor.author | Akahori, Hirokuni | - |
dc.contributor.author | Karmali, Vinit | - |
dc.contributor.author | Polavarapu, Rohini | - |
dc.contributor.author | Lyle, Alicia N. | - |
dc.contributor.author | Weiss, Daiana | - |
dc.contributor.author | Shin, Eric | - |
dc.contributor.author | Husain, Ahsan | - |
dc.contributor.author | Naqvi, Nawazish | - |
dc.contributor.author | Van Dam, Richard | - |
dc.contributor.author | Habib, Anwer | - |
dc.contributor.author | Choi, Cheol Ung | - |
dc.contributor.author | King, Adrienne L. | - |
dc.contributor.author | Pachura, Kimberly | - |
dc.contributor.author | Taylor, W. Robert | - |
dc.contributor.author | Lefer, David J. | - |
dc.contributor.author | Finn, Aloke V. | - |
dc.date.accessioned | 2021-09-04T13:53:49Z | - |
dc.date.available | 2021-09-04T13:53:49Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92888 | - |
dc.description.abstract | Macrophages are an essential component of the immune response to ischaemic injury and play an important role in promoting inflammation and its resolution, which is necessary for tissue repair. The type I transmembrane glycoprotein CD163 is exclusively expressed on macrophages, where it acts as a receptor for haemoglobin: haptoglobin complexes. An extracellular portion of CD163 circulates in the blood as a soluble protein, for which no physiological function has so far been described. Here we show that during ischaemia, soluble CD163 functions as a decoy receptor for TWEAK, a secreted pro-inflammatory cytokine of the tumour necrosis factor family, to regulate TWEAK-induced activation of canonical nuclear factor-kappa B (NF-kappa B) and Notch signalling necessary for myogenic progenitor cell proliferation. Mice with deletion of CD163 have transiently elevated levels of TWEAK, which stimulate muscle satellite cell proliferation and tissue regeneration in their ischaemic and non-ischaemic limbs. These results reveal a role for soluble CD163 in regulating muscle regeneration after ischaemic injury. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | (TNF)-LIKE WEAK INDUCER | - |
dc.subject | APOPTOSIS TWEAK | - |
dc.subject | SKELETAL-MUSCLE | - |
dc.subject | NOTCH | - |
dc.subject | GROWTH | - |
dc.subject | PATHWAY | - |
dc.subject | LIGAND | - |
dc.subject | ACTIVATION | - |
dc.subject | INHIBITION | - |
dc.title | CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Cheol Ung | - |
dc.identifier.doi | 10.1038/ncomms8792 | - |
dc.identifier.scopusid | 2-s2.0-84939150626 | - |
dc.identifier.wosid | 000360340700001 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.6 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | (TNF)-LIKE WEAK INDUCER | - |
dc.subject.keywordPlus | APOPTOSIS TWEAK | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | NOTCH | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INHIBITION | - |
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