Impact of Metabolic Syndrome on Subclinical Atherosclerosis in Asymptomatic Individuals
DC Field | Value | Language |
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dc.contributor.author | Park, Gyung-Min | - |
dc.contributor.author | An, Hyonggin | - |
dc.contributor.author | Lee, Seung-Whan | - |
dc.contributor.author | Cho, Young-Rak | - |
dc.contributor.author | Gil, Eun Ha | - |
dc.contributor.author | Her, Sung Ho | - |
dc.contributor.author | Park, Hyun Woo | - |
dc.contributor.author | Ahn, Jung-Min | - |
dc.contributor.author | Park, Duk-Woo | - |
dc.contributor.author | Kang, Soo-Jin | - |
dc.contributor.author | Kim, Young-Hak | - |
dc.contributor.author | Lee, Cheol Whan | - |
dc.contributor.author | Yang, Dong Hyun | - |
dc.contributor.author | Kang, Joon-Won | - |
dc.contributor.author | Lim, Tae-Hwan | - |
dc.contributor.author | Kim, Hong-Kyu | - |
dc.contributor.author | Choe, Jaewon | - |
dc.contributor.author | Park, Seong-Wook | - |
dc.contributor.author | Park, Seung-Jung | - |
dc.date.accessioned | 2021-09-04T13:54:07Z | - |
dc.date.available | 2021-09-04T13:54:07Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 1346-9843 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92890 | - |
dc.description.abstract | Background: Little is known about subclinical atherosclerosis on coronary computed tomographic angiography (CCTA) in asymptomatic individuals with metabolic syndrome (MetS). Methods and Results: We analyzed 5,213 asymptomatic individuals who underwent CCTA. A cardiac event was defined as a composite of all-cause death, myocardial infarction, unstable angina, or coronary revascularization. Of the study participants, 2,042 (39.2%) had MetS. MetS was an independent predictor of significant coronary artery disease (CAD) in at least 1 coronary artery (odds ratio [OR]=1.992, 95% confidence interval [CI]=1.623-2.445, P<0.001) and significant CAD in the left main (LM) or proximal left anterior descending (LAD) artery (OR=2.151, 95% CI=1.523-3.037, P<0.001). During the follow-up period (median 28.1 [interquartile range, 19.2-36.5] months), 111 individuals had 114 cardiac events. Individuals with MetS were significantly associated with more cardiac events than those without (RR [rate ratio]=1.67, 95% CI=1.15-2.43, P=0.007). In the MetS group, individuals with significant CAD had the majority of cardiac events (RR=64.33, 95% CI=29.17-141.88, P<0.001). Furthermore, in the MetS with significant CAD group, those with significant CAD in the LM or proximal LAD had more cardiac events (RR=2.63, 95% CI=1.51-4.59, P=0.001). Conclusions: MetS was associated with subclinical atherosclerosis on CCTA with subsequent high risk for cardiac events. These findings suggest the importance of reducing unfavorable metabolic conditions in asymptomatic individuals. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | JAPANESE CIRCULATION SOC | - |
dc.subject | CORONARY-ARTERY-DISEASE | - |
dc.subject | COMPUTED TOMOGRAPHIC ANGIOGRAPHY | - |
dc.subject | PROGNOSTIC VALUE | - |
dc.subject | DIABETES-MELLITUS | - |
dc.subject | RISK | - |
dc.subject | PLAQUES | - |
dc.subject | CT | - |
dc.subject | PREDICTION | - |
dc.subject | MORTALITY | - |
dc.subject | ACCURACY | - |
dc.title | Impact of Metabolic Syndrome on Subclinical Atherosclerosis in Asymptomatic Individuals | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | An, Hyonggin | - |
dc.identifier.doi | 10.1253/circj.CJ-14-1197 | - |
dc.identifier.scopusid | 2-s2.0-84937867440 | - |
dc.identifier.wosid | 000358572900028 | - |
dc.identifier.bibliographicCitation | CIRCULATION JOURNAL, v.79, no.8, pp.1799 - 1806 | - |
dc.relation.isPartOf | CIRCULATION JOURNAL | - |
dc.citation.title | CIRCULATION JOURNAL | - |
dc.citation.volume | 79 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1799 | - |
dc.citation.endPage | 1806 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | CORONARY-ARTERY-DISEASE | - |
dc.subject.keywordPlus | COMPUTED TOMOGRAPHIC ANGIOGRAPHY | - |
dc.subject.keywordPlus | PROGNOSTIC VALUE | - |
dc.subject.keywordPlus | DIABETES-MELLITUS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | PLAQUES | - |
dc.subject.keywordPlus | CT | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | Coronary artery disease | - |
dc.subject.keywordAuthor | Metabolic syndrome | - |
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