Blood-brain barrier-permeable fluorone-labeled dieckols acting as neuronal ER stress signaling inhibitors
DC Field | Value | Language |
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dc.contributor.author | Kwak, Jong Hwan | - |
dc.contributor.author | Yang, Zhigang | - |
dc.contributor.author | Yoon, Byungkwon | - |
dc.contributor.author | He, Yanxia | - |
dc.contributor.author | Uhm, Soojin | - |
dc.contributor.author | Shin, Hyeon-Cheol | - |
dc.contributor.author | Lee, Bong Ho | - |
dc.contributor.author | Yoo, Yung Choon | - |
dc.contributor.author | Lee, Kyung Bok | - |
dc.contributor.author | Han, Seung-Yun | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2021-09-04T13:59:41Z | - |
dc.date.available | 2021-09-04T13:59:41Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92933 | - |
dc.description.abstract | We studied the blood-brain barrier (BBB) permeability and intracellular localization of a fluorescein isothiocyanate (FITC)-labeled dieckol (I) and a rhodamine B-labeled dieckol (7), for exploring the possible therapeutic application of fluorone-labeled dieckols in neurodegenerative diseases. Both compounds (1 & 7) were synthesized through a click reaction and were found to be localized in the endoplasmic reticulum (ER) of the two types of brain cell lines (SH-SY5Y and BV-2 cells) tested; they also reduced ER stress in the SH-SY5Y human neuroblastoma cells. In addition, 1 and 7 were shown to pass the BBB in rats upon intravenous administration. Altogether, our study demonstrates, for the first time, that targeted ER-stress reduction in brain cells can be achieved by introducing fluorone dieckol conjugates into systemic circulation. Therefore, 1 and 7 provide a novel and promising ER-targeting therapeutic strategy for neurodegenerative diseases. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject | NEURODEGENERATIVE DISEASES | - |
dc.subject | BROWN ALGA | - |
dc.subject | ECKLONIA-STOLONIFERA | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | PC12 CELLS | - |
dc.subject | PHLOROTANNINS | - |
dc.subject | ACETYLCHOLINESTERASE | - |
dc.subject | ANTIOXIDANTS | - |
dc.subject | ANTIBIOTICS | - |
dc.title | Blood-brain barrier-permeable fluorone-labeled dieckols acting as neuronal ER stress signaling inhibitors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1016/j.biomaterials.2015.04.045 | - |
dc.identifier.scopusid | 2-s2.0-84939188835 | - |
dc.identifier.wosid | 000357229900006 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.61, pp.52 - 60 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 61 | - |
dc.citation.startPage | 52 | - |
dc.citation.endPage | 60 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject.keywordPlus | NEURODEGENERATIVE DISEASES | - |
dc.subject.keywordPlus | BROWN ALGA | - |
dc.subject.keywordPlus | ECKLONIA-STOLONIFERA | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | PC12 CELLS | - |
dc.subject.keywordPlus | PHLOROTANNINS | - |
dc.subject.keywordPlus | ACETYLCHOLINESTERASE | - |
dc.subject.keywordPlus | ANTIOXIDANTS | - |
dc.subject.keywordPlus | ANTIBIOTICS | - |
dc.subject.keywordAuthor | Fluorone-labeled dieckols | - |
dc.subject.keywordAuthor | Click reaction | - |
dc.subject.keywordAuthor | Blood-brain barrier | - |
dc.subject.keywordAuthor | Endoplasmic reticulum (ER) stress | - |
dc.subject.keywordAuthor | ER localization | - |
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