Synthesis Mechanism and Thermal Optimization of an Economical Mesoporous Material Using Silica: Implications for the Effective Removal or Delivery of Ibuprofen
DC Field | Value | Language |
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dc.contributor.author | Kittappa, Shanmuga | - |
dc.contributor.author | Cui, Mingcan | - |
dc.contributor.author | Ramalingam, Malarvili | - |
dc.contributor.author | Ibrahim, Shaliza | - |
dc.contributor.author | Khim, Jeehyeong | - |
dc.contributor.author | Yoon, Yeomin | - |
dc.contributor.author | Snyder, Shane A. | - |
dc.contributor.author | Jang, Min | - |
dc.date.accessioned | 2021-09-04T14:17:17Z | - |
dc.date.available | 2021-09-04T14:17:17Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2015-07-10 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93018 | - |
dc.description.abstract | Mesoporous silica materials (MSMs) were synthesized economically using silica (SiO2) as a precursor via a modified alkaline fusion method. The MSM prepared at 500 degrees C (MSM-500) had the highest surface area, pore size, and volume, and the results of isotherms and the kinetics of ibuprofen (IBP) removal indicated that MSM-500 had the highest sorption capacity and fastest removal speed vs. SBA-15 and zeolite. Compared with commercial granular activated carbon (GAC), MSM-500 had a similar to 100 times higher sorption rate at neutral pH. IBP uptake by MSM-500 was thermodynamically favorable at room temperature, which was interpreted as indicating relatively weak bonding because the entropy (Delta(adsS), -0.07 J mol(-1) K-1) was much smaller. Five times recycling tests revealed that MSM-500 had 83-87% recovery efficiencies and slower uptake speeds due to slight deformation of the outer pore structure. In the IBP delivery test, MSM-500 drug loading was 41%, higher than the reported value of SBA-15 (31%). The in vitro release of IBP was faster, almost 100%, reaching equilibrium within a few hours, indicating its effective loading and unloading characteristics. A cost analysis study revealed that the MSM was similar to 10-70 times cheaper than any other mesoporous silica material for the removal or delivery of IBP. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | ACTIVATED CARBONS | - |
dc.subject | PHARMACEUTICAL COMPOUNDS | - |
dc.subject | SURFACE-CHEMISTRY | - |
dc.subject | MOLECULAR-SIEVES | - |
dc.subject | ADSORPTION | - |
dc.subject | SBA-15 | - |
dc.subject | MCM-41 | - |
dc.subject | NANOPARTICLES | - |
dc.subject | COPOLYMER | - |
dc.title | Synthesis Mechanism and Thermal Optimization of an Economical Mesoporous Material Using Silica: Implications for the Effective Removal or Delivery of Ibuprofen | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Khim, Jeehyeong | - |
dc.identifier.doi | 10.1371/journal.pone.0130253 | - |
dc.identifier.scopusid | 2-s2.0-84940421591 | - |
dc.identifier.wosid | 000358162300016 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.10, no.7 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | ACTIVATED CARBONS | - |
dc.subject.keywordPlus | PHARMACEUTICAL COMPOUNDS | - |
dc.subject.keywordPlus | SURFACE-CHEMISTRY | - |
dc.subject.keywordPlus | MOLECULAR-SIEVES | - |
dc.subject.keywordPlus | ADSORPTION | - |
dc.subject.keywordPlus | SBA-15 | - |
dc.subject.keywordPlus | MCM-41 | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | COPOLYMER | - |
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