Enhancing Proliferation and ECM Expression of Human ACL Fibroblasts by Sonic Vibration
DC Field | Value | Language |
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dc.contributor.author | Jiang, Yuan-Yuan | - |
dc.contributor.author | Park, Jung-Keug | - |
dc.contributor.author | Yoon, Hee-Hoon | - |
dc.contributor.author | Choi, Hynjin | - |
dc.contributor.author | Kim, Chan-Wha | - |
dc.contributor.author | Seo, Young-Kwon | - |
dc.date.accessioned | 2021-09-04T14:20:45Z | - |
dc.date.available | 2021-09-04T14:20:45Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2015-07-04 | - |
dc.identifier.issn | 1082-6068 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93034 | - |
dc.description.abstract | Effects of mechanical vibration on cell activity and behavior remain controversial: There has been evidence on both positive and negative effects. Furthermore, research on the anterior cruciate ligament (ACL) has as yet been limited and the frequency-related effects remain unknown, even though ACL injury is common and an injured ACL hardly spontaneously recovers. The object of this work was to address the influence of mechanical vibration on ACL fibroblasts, to determine the effects of frequencies, and to further study this effect at the cellular level. We found that sonic vibration affected ACL fibroblasts' proliferation and metabolism in a frequency-dependent manner, and 20Hz gave rise to the most ACL cell activity and comprehensively increased extracellular matrix (ECM) contents, including collagen type I, collagen type III, fibronectin, elastin, tenascin, glycosaminoglycan (GAG), and the cytoskeleton protein vimentin. Thus, our results indicate that sonic vibration possesses frequency-dependent effects on proliferation and productivity of ACL fibroblast with an optimal frequency of 20Hz under the present stimulation conditions, providing further information for future research in how vibrational stimulation manipulates ACL cellular behavior. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.subject | ANTERIOR CRUCIATE LIGAMENT | - |
dc.subject | WHOLE-BODY VIBRATION | - |
dc.subject | MESENCHYMAL STEM-CELLS | - |
dc.subject | MECHANICAL VIBRATION | - |
dc.subject | PATELLAR TENDON | - |
dc.subject | FREQUENCY | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | COLLAGEN | - |
dc.subject | STIMULATION | - |
dc.subject | RESPONSES | - |
dc.title | Enhancing Proliferation and ECM Expression of Human ACL Fibroblasts by Sonic Vibration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chan-Wha | - |
dc.identifier.doi | 10.1080/10826068.2014.923444 | - |
dc.identifier.scopusid | 2-s2.0-84908375426 | - |
dc.identifier.wosid | 000342817900007 | - |
dc.identifier.bibliographicCitation | PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY, v.45, no.5, pp.476 - 490 | - |
dc.relation.isPartOf | PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY | - |
dc.citation.title | PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY | - |
dc.citation.volume | 45 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 476 | - |
dc.citation.endPage | 490 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | ANTERIOR CRUCIATE LIGAMENT | - |
dc.subject.keywordPlus | WHOLE-BODY VIBRATION | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | MECHANICAL VIBRATION | - |
dc.subject.keywordPlus | PATELLAR TENDON | - |
dc.subject.keywordPlus | FREQUENCY | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordAuthor | extracellular matrix | - |
dc.subject.keywordAuthor | human anterior cruciate ligament fibroblast | - |
dc.subject.keywordAuthor | proliferation | - |
dc.subject.keywordAuthor | sonic vibration | - |
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