Low Serum Concentrations of Moxifloxacin, Prothionamide, and Cycloserine on Sputum Conversion in Multi-Drug Resistant TB
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung Heon | - |
dc.contributor.author | Seo, Kyung-Ah | - |
dc.contributor.author | Lee, Young Min | - |
dc.contributor.author | Lee, Hyun-Kyung | - |
dc.contributor.author | Kim, Je Hyeong | - |
dc.contributor.author | Shin, Chol | - |
dc.contributor.author | Ghim, Jong-Ryul | - |
dc.contributor.author | Shin, Jae-Gook | - |
dc.contributor.author | Kim, Dong Hyun | - |
dc.date.accessioned | 2021-09-04T14:22:15Z | - |
dc.date.available | 2021-09-04T14:22:15Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2015-07-01 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93046 | - |
dc.description.abstract | Purpose: Low serum concentrations of drugs used to treat multi-drug resistant tuberculosis (MDR-TB) have occasionally been associated with treatment failure. We determined the frequencies of low serum concentrations of anti-MDR-TB drugs, and assessed the effects of these concentrations on 2-month sputum conversion. Materials and Methods: The serum levels of moxifloxacin (MF), prothionamide (PTH), and cycloserine (CS) were determined for 89 serum samples by high-pressure liquid chromatography-tandem mass spectrometry. Results: Low serum concentrations of MF, PTH, and CS below the minimal levels of the normal ranges were 83.3% (20/24), 59.2% (29/49), and 71.2% (47/66), respectively. There were no significant differences between the 2-month sputum conversion group (n=25) and the 2-month sputum non-conversion group (n=4) in median drug concentrations (mu g/mL) of MF (1.46 vs. 1.60), PTH (0.91 vs. 0.70), and CS (14.90 vs. 14.90). However, a poor compliance rate was significantly greater in the 2-month sputum non-conversion group (75.0%, 3/4) than in the 2-month sputum conversion group (0%, 0/25) (p=0.001). Conclusion: The frequency of low serum concentrations of anti-MDR-TB drugs was substantial and might not affect the 2-month sputum conversion rate. Larger prospective studies with timely sampling are needed to investigate the role of therapeutic drug monitoring in MDR-TB. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.subject | DRUG-RESISTANCE | - |
dc.subject | TREATMENT OUTCOMES | - |
dc.subject | TUBERCULOSIS | - |
dc.subject | PHARMACOKINETICS | - |
dc.subject | HIV | - |
dc.subject | PLASMA | - |
dc.title | Low Serum Concentrations of Moxifloxacin, Prothionamide, and Cycloserine on Sputum Conversion in Multi-Drug Resistant TB | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Seung Heon | - |
dc.contributor.affiliatedAuthor | Kim, Je Hyeong | - |
dc.contributor.affiliatedAuthor | Shin, Chol | - |
dc.identifier.doi | 10.3349/ymj.2015.56.4.961 | - |
dc.identifier.scopusid | 2-s2.0-84931073781 | - |
dc.identifier.wosid | 000356902800011 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.56, no.4, pp.961 - 967 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 56 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 961 | - |
dc.citation.endPage | 967 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002002997 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | DRUG-RESISTANCE | - |
dc.subject.keywordPlus | TREATMENT OUTCOMES | - |
dc.subject.keywordPlus | TUBERCULOSIS | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | HIV | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordAuthor | Tuberculosis | - |
dc.subject.keywordAuthor | multidrug resistance | - |
dc.subject.keywordAuthor | moxifloxacin | - |
dc.subject.keywordAuthor | prothionamide | - |
dc.subject.keywordAuthor | cycloserine | - |
dc.subject.keywordAuthor | drug monitoring | - |
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