Efficacy of Poly-Gamma-Glutamic Acid in Women with High-Risk Human Papillomavirus-Positive Vaginal Intraepithelial Neoplasia: an Observational Pilot Study
DC Field | Value | Language |
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dc.contributor.author | Koo, Yu-Jin | - |
dc.contributor.author | Min, Kyung-Jin | - |
dc.contributor.author | Hong, Jin-Hwa | - |
dc.contributor.author | Lee, Jae-Kwan | - |
dc.date.accessioned | 2021-09-04T14:24:53Z | - |
dc.date.available | 2021-09-04T14:24:53Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93064 | - |
dc.description.abstract | Poly-gamma-glutamic acid (gamma-PGA) is a natural polymer that is synthesized by Bacillus species and has been reported to have antitumor activity. The aim of this study was to investigate the effect of gamma-PGA on the treatment of vaginal intraepithelial neoplasia (VAIN). A retrospective observational study on gamma-PGA therapy for biopsy-proven VAIN was conducted. The efficacy was assessed by evaluating the results of Pap cytology and the viral load of high-risk HPV at three time points: at enrollment, and at the first and second post-treatment visits. Of 17 patients treated with gamma-PGA, only 12 patients who had a high-risk HPV infection were included in the analysis. Histology was VAIN1 in seven patients, VAIN2 in two patients, and VAIN3 in three patients. gamma-PGA was administered for newly diagnosed VAIN in five (41.7%) patients and persistent VAIN in seven (58.3%) patients for the mean time of 4.5 months. At the first and second post-treatment visits, cytological regression was observed in five (41.7%) and six (50%) patients, respectively. Regarding the HPV load, the overall response rate was 66.7%, and the mean level was 670.6 +/- 292.5 RLU at the first follow-up, which was lower than the initial viral load of 1,494.8 +/- 434.5 RLU (p = 0.084). At the second follow-up, the overall response rate was 58.3%, and the mean viral load level was 924.2 +/- 493.7 RLU. gamma-PGA may be helpful for the cytological regression and reduction of viral load in patients with high-risk HPV-positive VAIN, suggesting that gamma-PGA is a promising treatment option for primary or persistent VAIN. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY | - |
dc.subject | UNITED-STATES | - |
dc.subject | MANAGEMENT | - |
dc.subject | PREVALENCE | - |
dc.subject | CANCERS | - |
dc.subject | VULVAR | - |
dc.title | Efficacy of Poly-Gamma-Glutamic Acid in Women with High-Risk Human Papillomavirus-Positive Vaginal Intraepithelial Neoplasia: an Observational Pilot Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Kyung-Jin | - |
dc.contributor.affiliatedAuthor | Hong, Jin-Hwa | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Kwan | - |
dc.identifier.doi | 10.4014/jmb.1503.03106 | - |
dc.identifier.scopusid | 2-s2.0-84937412208 | - |
dc.identifier.wosid | 000358701800023 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.25, no.7, pp.1163 - 1169 | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.citation.title | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.citation.volume | 25 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1163 | - |
dc.citation.endPage | 1169 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002014189 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | UNITED-STATES | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | CANCERS | - |
dc.subject.keywordPlus | VULVAR | - |
dc.subject.keywordAuthor | Poly-gamma-glutamic acid | - |
dc.subject.keywordAuthor | vaginal intraepithelial neoplasia | - |
dc.subject.keywordAuthor | human papillomavirus | - |
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