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Novel Germline Mutation of BRCA1 Gene in a 56-Year-Old Woman with Breast Cancer, Ovarian Cancer, and Diffuse Large B-Cell Lymphoma
- Authors
- Kim, Hye Sook; Lee, Soon Wook; Choi, Yoon Ji; Shin, Sang Won; Kim, Yeul Hong; Cho, Min Sun; Lee, Soon Nam; Park, Kyong Hwa
- Issue Date
- 7월-2015
- Publisher
- KOREAN CANCER ASSOCIATION
- Keywords
- BRCA1 gene; Breast neoplasms; Lymphoma; Ovarian neoplasms
- Citation
- CANCER RESEARCH AND TREATMENT, v.47, no.3, pp.534 - 538
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- CANCER RESEARCH AND TREATMENT
- Volume
- 47
- Number
- 3
- Start Page
- 534
- End Page
- 538
- ISSN
- 1598-2998
- Abstract
- We report a case of a 56-year-old woman with breast cancer, ovarian cancer, and diffuse large B-cell lymphoma with a BRCA1 gene mutation. Evidence is mounting that there is a large increase in the risk for hematologic malignancies among patients with genetic changes in the BRCA pathways. The genomic analysis demonstrated a frameshift mutation in the BRCA1 gene: 277_279delinsCC (Phe93fs). It is a novel BRCA1 mutation that has never been reported, and caused malignant lymphoma as well as breast and ovarian cancer.
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