Clinical Impact of Intravascular Ultrasound-Guided Chronic Total Occlusion Intervention With Zotarolimus-Eluting Versus Biolimus-Eluting Stent Implantation Randomized Study
DC Field | Value | Language |
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dc.contributor.author | Kim, Byeong-Keuk | - |
dc.contributor.author | Shin, Dong-Ho | - |
dc.contributor.author | Hong, Myeong-Ki | - |
dc.contributor.author | Park, Hun Sik | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Mintz, Gary S. | - |
dc.contributor.author | Kim, Jung-Sun | - |
dc.contributor.author | Kim, Je Sang | - |
dc.contributor.author | Lee, Seung-Jin | - |
dc.contributor.author | Kim, Hee-Yeol | - |
dc.contributor.author | Hong, Bum-Kee | - |
dc.contributor.author | Kang, Woong-Chol | - |
dc.contributor.author | Choi, Jin-Ho | - |
dc.contributor.author | Jang, Yangsoo | - |
dc.date.accessioned | 2021-09-04T14:55:47Z | - |
dc.date.available | 2021-09-04T14:55:47Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.issn | 1941-7640 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93203 | - |
dc.description.abstract | Background-There have been no randomized studies comparing intravascular ultrasound (IVUS)-guided versus conventional angiography-guided chronic total occlusion (CTO) intervention using new-generation drug-eluting stent Therefore, we conducted a prospective, randomized, multicenter trial designed to test the hypothesis that IVUS-guided CTO intervention is superior to angiography-guided intervention. Methods and Results-After successful guidewire crossing, 402 patients with CTOs were randomized to the IVUS-guided group (n=201) or the angiography-guided group (n=201) and secondarily randomized to Resolute zotarolimus-eluting stents or Nobori biolimus-eluting stents. The primary and secondary end points were cardiac death and a major adverse cardiac event defined as the composite of cardiac death, myocardial infarction, or target-vessel revascularization, respectively. After 12-month follow-up, the rate of cardiac death was not significantly different between the IVUS-guided group (0%) and the angiography-guided group (1.0%; P by log-rank test=0.16). However, major adverse cardiac event rates were significantly lower in the IVUS-guided group than that in the angiography-guided group (2.6% versus 7.1%; P=0.035; hazard ratio, 0.35; 95% confidence interval, 0.13-0.97). Occurrence of the composite of cardiac death or myocardial infarction was significantly lower in the IVUS-guided group (0%) than in the angiography-guided group (2.0%; P=0.045). The rates of target-vessel revascularization were not significantly different between the 2 groups. In the comparison between Resolute zotarolimus-eluting stent and Nobori biolimus-eluting stent, major adverse cardiac event rates were not significantly different (4.0% versus 5.7%; P=0.45). Conclusions-Although IVUS-guided CTO intervention did not significantly reduce cardiac mortality, this randomized study demonstrated that IVUS-guided CTO intervention might improve 12-month major adverse cardiac event rate after new-generation drug-eluting stent implantation when compared with conventional angiography-guided CTO intervention. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject | EXPERT CONSENSUS DOCUMENT | - |
dc.subject | NON-INFERIORITY TRIAL | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | PROCEDURAL OUTCOMES | - |
dc.subject | ARTERY STENOSES | - |
dc.subject | ANGIOGRAPHY | - |
dc.subject | REGISTRY | - |
dc.subject | REVASCULARIZATION | - |
dc.subject | RECANALIZATION | - |
dc.title | Clinical Impact of Intravascular Ultrasound-Guided Chronic Total Occlusion Intervention With Zotarolimus-Eluting Versus Biolimus-Eluting Stent Implantation Randomized Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rha, Seung-Woon | - |
dc.identifier.doi | 10.1161/CIRCINTERVENTIONS.115.002592 | - |
dc.identifier.scopusid | 2-s2.0-84942814922 | - |
dc.identifier.wosid | 000390404100009 | - |
dc.identifier.bibliographicCitation | CIRCULATION-CARDIOVASCULAR INTERVENTIONS, v.8, no.7 | - |
dc.relation.isPartOf | CIRCULATION-CARDIOVASCULAR INTERVENTIONS | - |
dc.citation.title | CIRCULATION-CARDIOVASCULAR INTERVENTIONS | - |
dc.citation.volume | 8 | - |
dc.citation.number | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject.keywordPlus | EXPERT CONSENSUS DOCUMENT | - |
dc.subject.keywordPlus | NON-INFERIORITY TRIAL | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | PROCEDURAL OUTCOMES | - |
dc.subject.keywordPlus | ARTERY STENOSES | - |
dc.subject.keywordPlus | ANGIOGRAPHY | - |
dc.subject.keywordPlus | REGISTRY | - |
dc.subject.keywordPlus | REVASCULARIZATION | - |
dc.subject.keywordPlus | RECANALIZATION | - |
dc.subject.keywordAuthor | coronary occlusion | - |
dc.subject.keywordAuthor | drug-eluting stents | - |
dc.subject.keywordAuthor | ultrasonography, interventional | - |
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