Insulin activates EGFR by stimulating its interaction with IGF-1R in low-EGFR-expressing TNBC cells
DC Field | Value | Language |
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dc.contributor.author | Shin, Miyoung | - |
dc.contributor.author | Yang, Eun Gyeong | - |
dc.contributor.author | Song, Hyun Kyu | - |
dc.contributor.author | Jeon, Hyesung | - |
dc.date.accessioned | 2021-09-04T14:58:57Z | - |
dc.date.available | 2021-09-04T14:58:57Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2015-06-30 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93226 | - |
dc.description.abstract | The expression of epidermal growth factor receptor (EGFR) is an important diagnostic marker for triple-negative breast cancer (TNBC)cells, which lack three hormonal receptors: estrogen and progesterone receptors as well as epidermal growth factor receptor 2. EGFR transactivation can cause drug resistance in many cancers including TNBC, but the mechanism underlying this phenomenon is poorly defined. Here, we demonstrate that insulin treatment induces EGFR activation by stimulating the interaction of EGFR with insulin-like growth factor receptor 1 (IGF-1R) in the MDA-MB-436 TNBC cell line. These cells express low levels of EGFR, while exhibiting high levels of IGF-1R expression and phosphorylation. Low-EGFR-expressing MDA-MB-436 cells show high sensitivity to insulin-stimulated cell growth. Therefore, unexpectedly, insulin stimulation induced EGFR transactivation by regulating its interaction with IGF-1R in low-EGFR-expressing TNBC cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.subject | GROWTH-FACTOR RECEPTOR | - |
dc.subject | FACTOR-I-RECEPTOR | - |
dc.subject | NEGATIVE BREAST-CANCER | - |
dc.subject | RESISTANCE | - |
dc.subject | INHIBITOR | - |
dc.subject | NEOPLASIA | - |
dc.subject | ERLOTINIB | - |
dc.subject | THERAPY | - |
dc.subject | NETWORK | - |
dc.subject | PATHWAY | - |
dc.title | Insulin activates EGFR by stimulating its interaction with IGF-1R in low-EGFR-expressing TNBC cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Hyun Kyu | - |
dc.identifier.doi | 10.5483/BMBRep.2015.48.6.157 | - |
dc.identifier.scopusid | 2-s2.0-84936160914 | - |
dc.identifier.wosid | 000358363200008 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.48, no.6, pp.342 - 347 | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 48 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 342 | - |
dc.citation.endPage | 347 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002000905 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | FACTOR-I-RECEPTOR | - |
dc.subject.keywordPlus | NEGATIVE BREAST-CANCER | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | NEOPLASIA | - |
dc.subject.keywordPlus | ERLOTINIB | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | NETWORK | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | EGFR activation | - |
dc.subject.keywordAuthor | IGF-1R interaction | - |
dc.subject.keywordAuthor | Insulin | - |
dc.subject.keywordAuthor | MDA-MB-436 | - |
dc.subject.keywordAuthor | Triple-negative breast cancer cells | - |
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