Enantioselective Synthesis of beta-Arylamines via Chiral Phosphoric Acid-Catalyzed Asymmetric Reductive Amination
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kyung-Hee | - |
dc.contributor.author | Lee, Chun-Young | - |
dc.contributor.author | Cheon, Cheol-Hong | - |
dc.date.accessioned | 2021-09-04T15:01:36Z | - |
dc.date.available | 2021-09-04T15:01:36Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2015-06-19 | - |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93244 | - |
dc.description.abstract | A new method for the synthesis of chiral beta-aryl amines via chiral phosphoric acid-catalyzed enantioselective reductive amination of benzyl methyl ketone derivatives with Hantzsch ester was developed. Various chiral beta-aryl amines were obtained in high yields and with good to high enantioselectivities. This transformation is applicable to gram-scale reactions, and the catalyst loading can be reduced to 1 mol % without sacrificing any catalytic efficacy. Furthermore, the resulting beta-aryl amine was successfully converted into a tetrahydroisoquinoline compound without any loss of enantioselectivity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | TRANSFER HYDROGENATION | - |
dc.subject | BRONSTED ACID | - |
dc.subject | DERIVATIVES | - |
dc.subject | KETONES | - |
dc.subject | ACTIVATION | - |
dc.subject | AMINES | - |
dc.subject | TETRAHYDROISOQUINOLINES | - |
dc.subject | BENZOTHIAZOLINE | - |
dc.subject | SEQUENCE | - |
dc.subject | IMINES | - |
dc.title | Enantioselective Synthesis of beta-Arylamines via Chiral Phosphoric Acid-Catalyzed Asymmetric Reductive Amination | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cheon, Cheol-Hong | - |
dc.identifier.doi | 10.1021/acs.joc.5b00812 | - |
dc.identifier.scopusid | 2-s2.0-84934909249 | - |
dc.identifier.wosid | 000356845800038 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ORGANIC CHEMISTRY, v.80, no.12, pp.6367 - 6374 | - |
dc.relation.isPartOf | JOURNAL OF ORGANIC CHEMISTRY | - |
dc.citation.title | JOURNAL OF ORGANIC CHEMISTRY | - |
dc.citation.volume | 80 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 6367 | - |
dc.citation.endPage | 6374 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | TRANSFER HYDROGENATION | - |
dc.subject.keywordPlus | BRONSTED ACID | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | KETONES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | AMINES | - |
dc.subject.keywordPlus | TETRAHYDROISOQUINOLINES | - |
dc.subject.keywordPlus | BENZOTHIAZOLINE | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | IMINES | - |
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