The insertion/deletion polymorphism in the angiotensin-converting enzyme and susceptibility to schizophrenia or Parkinson's disease: A meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-04T15:21:57Z | - |
dc.date.available | 2021-09-04T15:21:57Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1470-3203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93328 | - |
dc.description.abstract | Introduction: The purpose of this study was to examine whether the insertion (I) and deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) confers susceptibility to schizophrenia and Parkinson's disease (PD). Materials and methods: A meta-analysis was performed of the associations between the ACE I/D polymorphism and schizophrenia and PD. Results: Thirteen studies with 2024 cases and 2230 controls comprising eight studies on schizophrenia and five on PD were included in the meta-analysis. The meta-analysis revealed no association between the ACE D allele and schizophrenia (OR = 0.990, 95% CI = 0.889-1.102, p = 0.856) or PD (OR = 1.067, 95% CI = 0.907-1.255, p = 0.433). Stratification by ethnicity indicated no association between the ACE D allele and schizophrenia in European, Asian, or Turkish ethnic groups (OR = 0.896, 95% CI = 0.566-1.419, p = 0.640; OR = 1.057, 95% CI = 0.903-1.238, p = 0.492; OR = 1.111, 95% CI = 0.889-1.389, p = 0.354, respectively). Ethnicity-specific meta-analysis was not conducted for PD because only one ethnic PD study was available. Conclusions: This meta-analysis found no association between the ACE I/D polymorphism and schizophrenia or PD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | GENETIC-POLYMORPHISM | - |
dc.subject | DELETION POLYMORPHISM | - |
dc.subject | AFFECTIVE-DISORDERS | - |
dc.subject | SUBSTANCE-P | - |
dc.subject | ASSOCIATION | - |
dc.subject | POLYDIPSIA | - |
dc.subject | FAMILY | - |
dc.title | The insertion/deletion polymorphism in the angiotensin-converting enzyme and susceptibility to schizophrenia or Parkinson's disease: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1177/1470320313495909 | - |
dc.identifier.scopusid | 2-s2.0-84930888371 | - |
dc.identifier.wosid | 000356313200027 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v.16, no.2, pp.434 - 442 | - |
dc.relation.isPartOf | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | - |
dc.citation.title | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | - |
dc.citation.volume | 16 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 434 | - |
dc.citation.endPage | 442 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | GENETIC-POLYMORPHISM | - |
dc.subject.keywordPlus | DELETION POLYMORPHISM | - |
dc.subject.keywordPlus | AFFECTIVE-DISORDERS | - |
dc.subject.keywordPlus | SUBSTANCE-P | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | POLYDIPSIA | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordAuthor | Angiotensin-converting enzyme | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | schizophrenia | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
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