A meta-analysis examining the association between the MUC5B rs35705950 T/G polymorphism and susceptibility to idiopathic pulmonary fibrosis
DC Field | Value | Language |
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dc.contributor.author | Lee, Min-Gu | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-04T15:24:23Z | - |
dc.date.available | 2021-09-04T15:24:23Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1023-3830 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93344 | - |
dc.description.abstract | To explore whether the mucin (MUC) 5B rs35705950 T/G polymorphism confers susceptibility to idiopathic pulmonary fibrosis (IPF). A meta-analysis was conducted to determine associations between the MUC5B rs35705950 T/G polymorphism and either IPF or connective tissue disease-associated interstitial lung disease (CTD-ILD). We used the allele contrast, recessive, dominant, and additive models. A total of 12 IPF studies comprising 2859 patients and 6901 controls and four CTD-ILD studies involving 903 patients and 3306 controls were included in the meta-analysis. There was a significant association between the Tallele of the MUC5B rs35705950 polymorphism and IPF in all subjects (OR 3.768, 95 % CI 2.935-4.836, p < 1.0 x 10(-8)). Analysis after stratification by ethnicity indicated that the Tallele was significantly associated with IPF in Europeans and Asians (OR 3.728, 95 % CI 2.858-4.863, p < 1.0 x 10(-8); OR 4.334, 95 % CI 2.186-8.594, p = 2.6 x 10(-6)). However, there was no association between the Tallele and CTD-ILD in all subjects (OR 1.130, 95 % CI 0.937-1.363, p = 0.200), and in Europeans and Asians. Subgroup analysis by CTD type revealed no association between the Tallele and systemic sclerosis-associated ILD (SSc-ILD) and other CTD-ILDs. The MUC5B rs35705950 T/G polymorphism confers susceptibility to IPF in Europeans and Asians, but is not associated with susceptibility to CTD-ILD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER BASEL AG | - |
dc.subject | GENOME-WIDE ASSOCIATION | - |
dc.subject | PROMOTER POLYMORPHISM | - |
dc.subject | SYSTEMIC-SCLEROSIS | - |
dc.subject | SARCOIDOSIS | - |
dc.subject | MORTALITY | - |
dc.subject | BIAS | - |
dc.title | A meta-analysis examining the association between the MUC5B rs35705950 T/G polymorphism and susceptibility to idiopathic pulmonary fibrosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1007/s00011-015-0829-6 | - |
dc.identifier.scopusid | 2-s2.0-84937764348 | - |
dc.identifier.wosid | 000354396700011 | - |
dc.identifier.bibliographicCitation | INFLAMMATION RESEARCH, v.64, no.6, pp.463 - 470 | - |
dc.relation.isPartOf | INFLAMMATION RESEARCH | - |
dc.citation.title | INFLAMMATION RESEARCH | - |
dc.citation.volume | 64 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 463 | - |
dc.citation.endPage | 470 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISM | - |
dc.subject.keywordPlus | SYSTEMIC-SCLEROSIS | - |
dc.subject.keywordPlus | SARCOIDOSIS | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | BIAS | - |
dc.subject.keywordAuthor | IPF | - |
dc.subject.keywordAuthor | MUC5B | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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