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Prevalence of Spirometrically-defined Restrictive Ventilatory Defect in Korea: The Fourth-2, 3, and Fifth Korean National Health and Nutrition Examination Survey, 2008-2012

Authors
Lee, Jung YeonHwang, Yong IlPark, Yong BumPark, Jae YongKim, Ki UkOh, Yeon-MokYoon, Hyoung KyuYoon, Ho IlSheen, Sueng SuLee, Sang YeubLee, Chang-HoonLee, Heung BumLim, Sung ChulJung, Sung SooOh, KyungwonKim, YunaChun, ChaeminYoo, Kwang Ha
Issue Date
6월-2015
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Epidemiology; Lung Diseases; Interstitial; Respiratory Function Tests; Tuberculosis; X-Rays
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.30, no.6, pp.725 - 732
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
30
Number
6
Start Page
725
End Page
732
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/93350
DOI
10.3346/jkms.2015.30.6.725
ISSN
1011-8934
Abstract
The aim of the study was to evaluate the prevalence of restrictive ventilatory defect and to determine the risk factors in subjects with spirometrically-defined restrictive ventilatory defect. We used the population-based, fourth-2, 3 (2008, 2009) and fifth (2010-2012) Korea National Health and Nutrition Examination Survey (KNHANES) to analyze 15,073 subjects, aged >= 40 yr who underwent spirometry. Chest radiographs were also analyzed to identify restrictive lung disease. Spirometrically-defined restrictive ventilatory defect (FEV1/FVC >= 70% and FVC < 80% of mean predicted value) was detected in 11.3% (n = 1,709) of subjects aged = 40 yr. The prevalence increased to 12.3% on using the lower limit of normal (LLN) criteria. Approximately 99.4% of subjects were classified as mild restrictive. Among these, 11.3% had inactive tuberculosis (TB) lesion, 2.2% cardiac disease, 2.0% previous operation scar or radiation injury and/or mediastinal disease, and 7.4% other pulmonary disease suggestive of restrictive lung diseases on chest radiograph. Evidence of previous TB history was independently associated with restrictive ventilatory defect (odds ratios [OR], 1.78; 95% confidence interval, 1.45-2.18) after adjustment for gender, age, smoking, area for residence and body mass index. The prevalence of restrictive ventilatory defect among the nationwide population in Korea was 11.3% with fixed ratio criterion and 12.3% with LLN criterion. Most cases were of the mild restrictive category and previous TB history is the independent risk factor for restrictive ventilatory defect.
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