Porohyperelastic anatomical models for hydrocephalus and idiopathic intracranial hypertension
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hakseung | - |
dc.contributor.author | Min, Byoung-Kyong | - |
dc.contributor.author | Park, Dae-Hyeon | - |
dc.contributor.author | Hawi, Stanley | - |
dc.contributor.author | Kim, Byung-Jo | - |
dc.contributor.author | Czosnyka, Zofia | - |
dc.contributor.author | Czosnyka, Marek | - |
dc.contributor.author | Sutcliffe, Michael P. F. | - |
dc.contributor.author | Kim, Dong-Joo | - |
dc.date.accessioned | 2021-09-04T15:28:51Z | - |
dc.date.available | 2021-09-04T15:28:51Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 0022-3085 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93378 | - |
dc.description.abstract | OBJECT Brain deformation can be seen in hydrocephalus and idiopathic intracranial hypertension (IIH) via medical images. The phenomenology of local effects, brain shift, and raised intracranial pressure and herniation are textbook concepts. However, there are still uncertainties regarding the specific processes that occur when brain tissue is subject to the mechanical stress of different temporal and spatial profiles of the 2 neurological disorders. Moreover, recent studies suggest that IIH and hydrocephalus may be diseases with opposite pathogenesis. Nevertheless, the similarities and differences between the 2 subjects have not been thoroughly investigated. METHODS An anatomical porohyperelastic finite element model was used to assess the brain tissue responses associated with hydrocephalus and IIH. The same set of boundary conditions, with the exception of brain loading for development of the transmantle pressure gradient, was applied for the 2 models. The distribution of stress and strain during tissue distortion is described by the mechanical parameters. RESULTS The results of both the hydrocephalus and IIH models correlated with pathological characteristics. For the hydrocephalus model, periventricular edema was associated with the presence of positive volumetric strain and void ratio in the lateral ventricle horns. By contrast, the IIH model revealed edema across the cerebral mantle, including the centrum semiovale, with a positive void ratio and volumetric strain. CONCLUSIONS The model simulates all the clinical features in correlation with the MR images obtained in patients with hydrocephalus and IIH, thus providing support for the role of the transmantle pressure gradient and capillary CSF absorption in CSF-related brain deformation. The finite element methods can be used for a better understanding of the pathophysiological mechanisms of neurological disorders associated with parenchymal volumetric fluctuation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC NEUROLOGICAL SURGEONS | - |
dc.subject | NORMAL-PRESSURE HYDROCEPHALUS | - |
dc.subject | SLIT VENTRICLE SYNDROME | - |
dc.subject | FINITE-ELEMENT MODEL | - |
dc.subject | OBSTRUCTIVE HYDROCEPHALUS | - |
dc.subject | PSEUDOTUMOR CEREBRI | - |
dc.subject | BRAIN | - |
dc.subject | BIOMECHANICS | - |
dc.subject | PATIENT | - |
dc.subject | CIRCULATION | - |
dc.subject | DISORDERS | - |
dc.title | Porohyperelastic anatomical models for hydrocephalus and idiopathic intracranial hypertension | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hakseung | - |
dc.contributor.affiliatedAuthor | Min, Byoung-Kyong | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Jo | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Joo | - |
dc.identifier.doi | 10.3171/2014.12.JNS14516 | - |
dc.identifier.scopusid | 2-s2.0-84938493360 | - |
dc.identifier.wosid | 000355031400010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROSURGERY, v.122, no.6, pp.1330 - 1340 | - |
dc.relation.isPartOf | JOURNAL OF NEUROSURGERY | - |
dc.citation.title | JOURNAL OF NEUROSURGERY | - |
dc.citation.volume | 122 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1330 | - |
dc.citation.endPage | 1340 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | NORMAL-PRESSURE HYDROCEPHALUS | - |
dc.subject.keywordPlus | SLIT VENTRICLE SYNDROME | - |
dc.subject.keywordPlus | FINITE-ELEMENT MODEL | - |
dc.subject.keywordPlus | OBSTRUCTIVE HYDROCEPHALUS | - |
dc.subject.keywordPlus | PSEUDOTUMOR CEREBRI | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | BIOMECHANICS | - |
dc.subject.keywordPlus | PATIENT | - |
dc.subject.keywordPlus | CIRCULATION | - |
dc.subject.keywordPlus | DISORDERS | - |
dc.subject.keywordAuthor | biomechanics | - |
dc.subject.keywordAuthor | bi-phase | - |
dc.subject.keywordAuthor | finite element model | - |
dc.subject.keywordAuthor | hydrocephalus | - |
dc.subject.keywordAuthor | idiopathic intracranial hypertension | - |
dc.subject.keywordAuthor | cerebrospinal fluid | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.