Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK
DC Field | Value | Language |
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dc.contributor.author | Lee, Hye Jeong | - |
dc.contributor.author | Lee, Jung Ok | - |
dc.contributor.author | Kim, Nami | - |
dc.contributor.author | Kim, Joong Kwan | - |
dc.contributor.author | Kim, Hyung Ip | - |
dc.contributor.author | Lee, Yong Woo | - |
dc.contributor.author | Kim, Su Jin | - |
dc.contributor.author | Choi, Jong-Il | - |
dc.contributor.author | Oh, Yoonji | - |
dc.contributor.author | Kim, Jeong Hyun | - |
dc.contributor.author | Suyeon-Hwang | - |
dc.contributor.author | Park, Sun Hwa | - |
dc.contributor.author | Kim, Hyeon Soo | - |
dc.date.accessioned | 2021-09-04T15:29:13Z | - |
dc.date.available | 2021-09-04T15:29:13Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 0888-8809 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93380 | - |
dc.description.abstract | Irisin is a novel myokine produced by skeletal muscle. However, its metabolic role is poorly understood. In the present study, irisin induced glucose uptake in differentiated skeletal muscle cells. It increased AMP-activated protein kinase (AMPK) phosphorylation and the inhibition of AMPK blocked glucose uptake. It also increased reactive oxygen species (ROS) generation. N-acetyl cysteine, a ROS scavenger, blocked irisin-induced AMPK phosphorylation. Moreover, irisin activated p38 MAPK in an AMPK-dependent manner. The inhibition and knockdown of p38 MAPK blocked irisin-induced glucose uptake. A colorimetric absorbance assay showed that irisin stimulated the translocation of glucose transporter type 4 to the plasma membrane and that this effect was suppressed in cells pretreated with a p38 MAPK inhibitor or p38 MAPK small interfering RNA. In primary cultured myoblast cells, irisin increased the concentration of intracellular calcium. STO-609, a calcium/calmodulin-dependent protein kinase kinase inhibitor, blocked irisin-induced AMPK phosphorylation, implying that calcium is involved in irisin-mediated signaling. Our results suggest that irisin plays an important role in glucose metabolism via the ROS-mediated AMPK pathway in skeletal muscle cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ENDOCRINE SOC | - |
dc.subject | ACTIVATED PROTEIN-KINASE | - |
dc.subject | INCREASES INSULIN SENSITIVITY | - |
dc.subject | CIRCULATING LEVELS | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | MAP KINASE | - |
dc.subject | GLUT4 | - |
dc.subject | BETA | - |
dc.subject | CONTRACTION | - |
dc.subject | TRANSPORT | - |
dc.title | Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Jong-Il | - |
dc.contributor.affiliatedAuthor | Kim, Hyeon Soo | - |
dc.identifier.doi | 10.1210/me.2014-1353 | - |
dc.identifier.scopusid | 2-s2.0-84929648291 | - |
dc.identifier.wosid | 000358534000008 | - |
dc.identifier.bibliographicCitation | MOLECULAR ENDOCRINOLOGY, v.29, no.6, pp.873 - 881 | - |
dc.relation.isPartOf | MOLECULAR ENDOCRINOLOGY | - |
dc.citation.title | MOLECULAR ENDOCRINOLOGY | - |
dc.citation.volume | 29 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 873 | - |
dc.citation.endPage | 881 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | INCREASES INSULIN SENSITIVITY | - |
dc.subject.keywordPlus | CIRCULATING LEVELS | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | MAP KINASE | - |
dc.subject.keywordPlus | GLUT4 | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | CONTRACTION | - |
dc.subject.keywordPlus | TRANSPORT | - |
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