Association between TNF-alpha promoter-308 A/G polymorphism and Alzheimer's disease: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-04T15:32:17Z | - |
dc.date.available | 2021-09-04T15:32:17Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1590-1874 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93402 | - |
dc.description.abstract | The aim of this study was to determine whether the tumor necrosis factor-alpha (TNF-alpha) promoter -308 A/G polymorphism is associated with susceptibility to Alzheimer's disease (AD) in multi-ethnic populations. MEDLINE and EMBASE databases and manual literature search were used to identify published articles in which TNF-alpha polymorphism was determined in AD patients and control subjects. Meta-analysis was conducted on the association between the TNF-alpha -308 A/G polymorphism and AD using allele contrast and the recessive, dominant, and additive models. A total of 16 studies involving 3,826 AD patients and 4,327 control subjects were examined. The meta-analysis showed no association between the TNF-alpha -308 A allele and AD when all the subjects were considered [odds ratio (OR) = 1.275, 95 % CI 0.966-1.685, p = 0.087]. After stratification by ethnicity, the meta-analysis indicated that the A allele is significantly associated with AD in East Asian (OR = 1.743, 95 % CI 1.256-2.418, p = 0.001), but not in the European (OR = 0.963, 95 % CI 0.822-1.128, p = 0.637) or Middle Eastern populations (OR = 3.921, 95 % CI 0.411-37.42, p = 0.235). Meta-analysis under dominant, recessive, and additive models also showed a similar pattern of results as with the A allele. This meta-analysis shows that the TNF-alpha -308 A/G polymorphism may represent a significant risk factor for AD in East Asians but not in the European or Middle Eastern populations. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER-VERLAG ITALIA SRL | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | RHEUMATOID-ARTHRITIS SUSCEPTIBILITY | - |
dc.subject | GENE POLYMORPHISM | - |
dc.subject | ONSET | - |
dc.subject | RISK | - |
dc.subject | POPULATION | - |
dc.subject | BETA | - |
dc.subject | AGE | - |
dc.subject | G-308A | - |
dc.subject | REGION | - |
dc.title | Association between TNF-alpha promoter-308 A/G polymorphism and Alzheimer's disease: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s10072-015-2102-8 | - |
dc.identifier.scopusid | 2-s2.0-84930382279 | - |
dc.identifier.wosid | 000355696700001 | - |
dc.identifier.bibliographicCitation | NEUROLOGICAL SCIENCES, v.36, no.6, pp.825 - 832 | - |
dc.relation.isPartOf | NEUROLOGICAL SCIENCES | - |
dc.citation.title | NEUROLOGICAL SCIENCES | - |
dc.citation.volume | 36 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 825 | - |
dc.citation.endPage | 832 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS SUSCEPTIBILITY | - |
dc.subject.keywordPlus | GENE POLYMORPHISM | - |
dc.subject.keywordPlus | ONSET | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | G-308A | - |
dc.subject.keywordPlus | REGION | - |
dc.subject.keywordAuthor | Tumor necrosis factor | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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