Fusion protein of retinol-binding protein and albumin domain III reduces liver fibrosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hongsik | - |
dc.contributor.author | Jeong, Hyeyeun | - |
dc.contributor.author | Park, Sangeun | - |
dc.contributor.author | Yoo, Wonbaek | - |
dc.contributor.author | Choi, Soyoung | - |
dc.contributor.author | Choi, Kyungmin | - |
dc.contributor.author | Lee, Min-Goo | - |
dc.contributor.author | Lee, Mihwa | - |
dc.contributor.author | Cha, DaeRyong | - |
dc.contributor.author | Kim, Young-Sik | - |
dc.contributor.author | Han, Jeeyoung | - |
dc.contributor.author | Kim, Wonkon | - |
dc.contributor.author | Park, Sun-Hwa | - |
dc.contributor.author | Oh, Junseo | - |
dc.date.accessioned | 2021-09-04T15:50:58Z | - |
dc.date.available | 2021-09-04T15:50:58Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1757-4676 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93464 | - |
dc.description.abstract | Activated hepatic stellate cells (HSCs) play a key role in liver fibrosis, and inactivating HSCs has been considered a promising therapeutic approach. We previously showed that albumin and its derivative designed for stellate cell-targeting, retinol-binding protein-albumin domain III fusion protein (referred to as R-III), inactivate cultured HSCs. Here, we investigated the mechanism of action of albumin/R-III in HSCs and examined the anti-fibrotic potential of R-III in vivo. R-III treatment and albumin expression downregulated retinoic acid (RA) signaling which was involved in HSC activation. RA receptor agonist and retinaldehyde dehydrogenase overexpression abolished the anti-fibrotic effect of R-III and albumin, respectively. R-III uptake into cultured HSCs was significantly decreased by siRNA-STRA6, and injected R-III was localized predominantly in HSCs in liver. Importantly, R-III administration reduced CCl4- and bile duct ligation-induced liver fibrosis. R-III also exhibited a preventive effect against CCl4-inducd liver fibrosis. These findings suggest that the anti-fibrotic effect of albumin/R-III is, at least in part, mediated by downregulation of RA signaling and that R-III is a good candidate as a novel anti-fibrotic drug. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | STELLATE CELL ACTIVATION | - |
dc.subject | VITAMIN-A | - |
dc.subject | TGF-BETA | - |
dc.subject | ACID | - |
dc.subject | SITES | - |
dc.title | Fusion protein of retinol-binding protein and albumin domain III reduces liver fibrosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hongsik | - |
dc.contributor.affiliatedAuthor | Lee, Min-Goo | - |
dc.contributor.affiliatedAuthor | Cha, DaeRyong | - |
dc.contributor.affiliatedAuthor | Kim, Young-Sik | - |
dc.contributor.affiliatedAuthor | Park, Sun-Hwa | - |
dc.contributor.affiliatedAuthor | Oh, Junseo | - |
dc.identifier.doi | 10.15252/emmm.201404527 | - |
dc.identifier.scopusid | 2-s2.0-84930180632 | - |
dc.identifier.wosid | 000355686400010 | - |
dc.identifier.bibliographicCitation | EMBO MOLECULAR MEDICINE, v.7, no.6, pp.819 - 830 | - |
dc.relation.isPartOf | EMBO MOLECULAR MEDICINE | - |
dc.citation.title | EMBO MOLECULAR MEDICINE | - |
dc.citation.volume | 7 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 819 | - |
dc.citation.endPage | 830 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | STELLATE CELL ACTIVATION | - |
dc.subject.keywordPlus | VITAMIN-A | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | SITES | - |
dc.subject.keywordAuthor | albumin | - |
dc.subject.keywordAuthor | anti-fibrotic drug | - |
dc.subject.keywordAuthor | fibrosis | - |
dc.subject.keywordAuthor | hepatic stellate cell | - |
dc.subject.keywordAuthor | retinoic acid | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.